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Science Friday

The Art And Science Of Staving Off Cognitive Decline

Science Friday

Science Friday and WNYC Studios

Science, Life Sciences, Wnyc, Natural Sciences, Friday

4.46.3K Ratings

🗓️ 2 March 2026

⏱️ 17 minutes

🧾️ Download transcript

Summary

A new comedic play and a 20-year neurology study explore what we can do to prevent dementia and cognitive decline.

Transcript

Click on a timestamp to play from that location

0:00.0

Hi, this is Ira Flato, and you're listening to Science Friday.

0:07.5

Today on the podcast, Josh is struggling with alcoholism, so he moves back home to get sober.

0:14.5

And then somewhat unexpectedly, he finds that his alcoholic-induced brain fog and memory loss are similar to what's happening

0:23.8

with his four aging grandparents. Josh reads about the idea of something called cognitive reserve

0:30.4

that doing brain-stimulating activities can prevent or delay the onset of dementia symptoms.

0:42.8

So he tries out some creative strategies to help both himself and his grandparents.

0:47.6

That's the plot of the semi-autobiographical play, The Reservoir,

0:50.3

the play received funding from the Sloan Foundation,

0:52.4

which also supports Science Friday.

0:54.5

It's currently running at the Atlantic Theater Company and co-produced by the Ensemble Studio Theater in New York. Joining me now is

0:59.7

the playwright Jake Brash. He's based in Brooklyn. Welcome to Science Friday. Thank you so much

1:04.7

for having me. Well, I loved it. It's a terrific play. It's a timely play. It's semi-bobiographical. Tell me how you came up with

1:12.5

the premise. So I actually started with the science. I was looking for something to pitch to the Sloan

1:17.3

Foundation and they came across this concept of cognitive reserve and looked at all of the factors,

1:22.9

you know, that one can try to improve in order to delay the onset of Alzheimer's symptoms and realize that

1:29.6

those are largely the things that one does to get sober. So I started there and then quickly realized,

1:34.9

oh my gosh, I'm writing about that year of my life. And I don't think I would have otherwise,

1:39.8

but the science was really what started it. And then ultimately, I knew I wanted to write a play about intergenerational connection

1:47.1

and grandparents and how much I loved my grandparents and also how my family copes with difficult

1:53.5

things through humor.

1:55.0

How did you go about weaving in the science?

1:57.3

And by that, I mean, did you really make sure the science was correct when you put it in there? Or did you use a lot of literary license in this? I mean, I hope the science is correct. Please, Sloan Foundation. I hope the science is correct. I, you know, first and foremost, it's a play, right? And I think it's important when you're trying to make art about science or sharing science, that the story itself is the most important

...

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