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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Tamsulosin Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 12 November 2020

⏱️ 12 minutes

🧾️ Download transcript

Summary

On this episode of the RLP podcast, I discuss tamsulosin pharmacology.



Tamsulosin inhibits alpha receptors which helps improve urine flow in patients with BPH.



As an off-label use, you may see tamsulosin used to try to aid in the passage of renal stones.



Tamsulosin concentrations may be increased by CYP3A4 inhibitors and reduced by CYP3A4 inducers.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, pharmacist Eric Christensen,

0:06.5

and I thank you so much for listening today. If you need a little resource, 31 page PDF, real life pharmacology.com,

0:17.0

go subscribe there and get that study guide for free. A little resource if you're, you know,

0:23.4

training students, residents, or if you're a student yourself, nurse, pharmacist, med student,

0:30.5

definitely go take advantage of that resource. It's a list of the top 200 drugs and some of the

0:36.4

most highly testable as well as real-life clinical pearls.

0:41.2

So again, go check that out at real-life pharmacology.com, and we'll also get you updates as to when we've got new podcasts and content available as well there.

0:50.9

Okay, so let's get into the drug of the day today, and that is Tamselocin.

0:56.8

The brand name of Tamselosin is Flomax, which maybe you can interpret a little bit from the name, the brand name of the drug to what it's used for.

1:09.4

Mechanistically, this drug is an alpha blocker.

1:13.7

And compared to other alpha blockers, so think of Teresacin, praisesin, those are considered

1:22.9

more non-selective alpha blockers.

1:26.7

Whereas tamselosin tends to do a better job of selectively

1:32.4

blocking alpha 1A receptors, which are primarily found in the process and urinary tract area.

1:43.2

Okay.

1:43.6

So what ends up happening by blocking the alpha 1A receptors, this leads to a relaxation

1:52.3

in smooth muscle in the prostate and bladder area, which ultimately helps improve urine flow.

2:01.0

Think of the brand name, Flow Max.

2:03.7

And so the indication or where this medication is going to be used primarily

2:07.7

or where I see it used in clinical practice most often

2:11.6

is for the management of BPH-type symptoms.

2:16.8

So remember that BPAH is basically this enlargement of the prostate

...

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