Studying Autism with BRAINS Grown In Space | Alysson Moutri on The INTO THE IMPOSSIBLE Podcast (#304)

Into the Impossible With Brian Keating

Brian Keating

Physics, Natural Sciences, Science

4.7 • 1.1K Ratings

🗓️ 20 March 2023

⏱️ 70 minutes

🔗️ Recording | iTunes | RSS

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Summary

Please support the podcast by taking our short listener survey: https://www.surveymonkey.com/r/intotheimpossible Be sure to watch the video of this episode on YouTube here: https://youtu.be/hDKGF5W4Qis?sub_confirmation=1 Where does consciousness come from? Can we cure autism? Can we grow a human BRAIN in Space? Dr. Alysson Muotri joins me to discuss all these fascinating questions and more. Brain organoids are lab-grown minibrains that mimic structural and functional features of full-size brains. They are created by culturing pluripotent stem cells in a three-dimensional rotational bioreactor, and they develop over a course of months. Brain organoids have emerged as novel model systems that can be used to investigate human brain development and disorders34, as well as evolutionary studies and neural network research Muotri is a Professor at the Departments of Pediatrics and Cellular & Molecular Medicine at UC San Diego, an Associate Director of CARTA, The Center for Research and Training in Anthropology, and Director of the Stem Cell Program, and of the Archealization Center (ArchC) at UC San Diego. He moved to the Salk Institute as Pew Latin America Fellow in 2002 for postdoctoral training in the fields of neuroscience and stem cell biology. His research focuses on brain evolution and modeling neurological diseases using human-induced pluripotent stem cells and brain organoids. He has an additional focus on solving one of life's greatest mysteries: What is it that makes us uniquely human? Our unique social brains are one of the key distinguishing factors between humans and other primates. We are even very different from our closest relatives, the Neanderthals. His work has implications for the generation of human disease models by determining the molecular and cellular mechanisms driving neurological complex disorders, such as autism. It is also creating opportunities for identifying and testing novel therapeutic approaches. Understanding the evolutionary path and the tradeoffs of the modern human brain will likely illuminate the origins of human disease. Dr. Moutri has received several awards, including the prestigious NIH Director’s New Innovator Award, NARSAD, Emerald Foundation Young Investigator Award, Surugadai Award, Rock Star of Innovation, NIH EUREKA Award, and two Telly Awards for Excellence in Science Communication. Links: Department of Cellular and Molecular Medicine: cmm.ucsd.edu Center for Academic Research and Training in Anthropogeny: carta.anthropogeny.org/users/alysson-muotri the Archealization Center: Archc.ucsd.edu Subscribe to the Jordan Harbinger Show for amazing content from Apple’s best podcast of 2018! https://www.jordanharbinger.com/podcasts Please leave a rating and review: On Apple devices, click here, https://apple.co/39UaHlB On Spotify it’s here: https://spoti.fi/3vpfXok On Audible it’s here https://tinyurl.com/wtpvej9v Find other ways to rate here: https://briankeating.com/podcast Support the podcast on Patreon https://www.patreon.com/drbriankeating or become a Member on YouTube- https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join To advertise with us, contact advertising@airwavemedia.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	Ivan my son now and I just fell in love I mean I didn't I didn't see autism I see
0:09.2	the individual he has difficulties on his daily life.
0:13.0	I mean, he's totally dependent because he has no sense of dangers.
0:16.3	He will cross the street and will put himself in a dangerous situation.
0:19.8	And he's no verbal, so he cannot say anything about, I mean what how is his feeling things like that
0:25.1	that creates some frustrations because you cannot express he's a big motivation now the
0:29.5	translational side I really want to to make sure my signs can help him and others like him to kind of cope with autism and daily life and become independent, right?
0:41.0	But on the other side, I don't want to lose him and my interactions with him otherwise I would be working like 24 hours and just doing that.
0:50.0	But I want to enjoy his life and that comes a challenge I mean how you do the same things
0:55.2	that we would do with we call neurotypical or normal person right but to be honest I mean
1:00.2	makes life unpredictable and I like it I've been enjoying the process.
1:04.6	What I would say to other parents or other families is not let the condition takes over your
1:09.3	life but embrace it.
1:11.3	I mean that's it.
1:12.3	I mean better days will come. I'm highly optimistic about that
1:15.6	But until there I mean trying to make the best of your life
1:30.0	Have you wondered what evolutionary milestones separated us from Neanderthals and other early hominies to give us language and civilization? What's the mechanism and genetic source code for neurodivergent conditions such as autism?
1:35.0	What happens to the brain during long duration space missions?
1:38.0	Are pluripotent stem cells, the gateway to a new era of medicine.
1:43.4	Our guest on this episode of Into the Impossible,
1:45.8	is celebrated UC San Diego neuroscientist
1:48.3	Professor Allison Mautry.
	...

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