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DR. GUNDRY PODCAST: GUT HEALTH, WEIGHT LOSS, AND NUTRITION

Spermidine Explained: The Anti-Aging Breakthrough You Need | EP 397.C

DR. GUNDRY PODCAST: GUT HEALTH, WEIGHT LOSS, AND NUTRITION

PodcastOne

Nutrition, Alternative Health, Health & Fitness, Medicine

4.61.8K Ratings

🗓️ 3 April 2026

⏱️ 19 minutes

🧾️ Download transcript

Summary

One of the most exciting discoveries in longevity science is a compound called spermidine. I explain how spermidine activates autophagy — your body’s natural “cellular cleanup” process — and how this powerful mechanism can support healthier aging, improved cellular function, and overall vitality.

Want a supplement with spermidine? Click here to try my Gundry MD Bio Sync: https://rebrand.ly/biosync-gundry-pod

For the episode's transcript: https://drgundry.com/ep-397-c-transcript

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Transcript

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0:00.0

A tiny compound is making big waves in the science of longevity.

0:14.3

It's got a funny name, but it's no joke when it comes to aging well.

0:19.7

It's called spermodyne. In just a minute, I'll tell you

0:23.0

how it works in the body to slow aging and I'll reveal the best foods with spermane. I'll be

0:29.7

right back after this brief message. Did you know the air inside your home could be up to 100 times more toxic than the air outside?

0:42.3

Chemicals from your furniture and cleaning products, invisible harmful particles from your stove and candles,

0:48.9

mold spores floating through every room. These toxic invaders are silently linked to brain fog, fatigue,

0:56.0

heart disease, and more. That's why I created Total Air. From my new home wellness brand, Homekind.

1:02.0

Total Air uses a true surgical-grade HEPA filter, the same standard I trusted in the operating room.

1:09.0

Plus an activated carbon layer for chemicals and

1:13.1

microband technology to stop mold and bacteria from spreading.

1:17.6

Three layers of medical grade protection, one device.

1:22.0

Clean air for you, your loved ones, even your pets.

1:25.4

Go to homekind.com right now and use code clean air for 10% off on total

1:32.7

air 180, Hepa 13 or 14. I built this to protect my family. Now it can protect yours too.

1:45.3

You know, there's a really interesting compound that occurs in nature, that occurs in several foods,

1:54.2

and maybe one of the kind of hidden secrets to longevity that you need to know about.

2:00.7

And I'm talking about spermadine.

2:04.0

You may recall a term called autophagy.

2:09.0

Atophagy actually means self-eat.

2:11.9

In aging, there are essentially two ways a old cell is destroyed.

2:20.1

One is called apoptosis.

...

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