SNR #87: Dr. Brendan Egan - Anabolic Resistance, Sarcopenia & The Importance of Muscle

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 15 September 2015

⏱️ 57 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode 87: Dr. Brendan Egan, PhD. from University College Dublin is on the show to discuss the concepts of net muscle protein balance, sarcopenia, anabolic resistance, interventions to overcome this and supplements like phosphatidic acid, HMB, creatine, leucine-enrichment.

Transcript

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0:00.0	You go back to that idea of stimuli and signal transduction and translation to muscle protein
0:11.3	synthesis, it's a really nice story because during heavy resistance training, so heavy
0:17.3	contractions, you do get this increase in phosphatitic acid within the muscle
0:22.1	cell.
0:23.1	The experimental data from cells does show that that activates muscle protein synthesis through
0:28.0	that pathway which you mentioned, which is entor.
0:32.0	There's an idea that inflammation itself as well can have the literal effect on anabolic
0:36.7	signal. If you look at just cross-sectional studies, for example, you'll see that there's an inverse
0:40.8	relationship between factors such as CRP or IL6 in the blood and you see that there's an inverse
0:47.9	relationship with NPS. Hello and welcome to episode 87 of Sigma Nutrition Radio.
1:05.8	My name is Danny Lennon.
1:07.4	And for those of you who are new to the podcast I want to say thank you for tuning in
1:11.7	and this show is just all about looking at the evidence base behind nutrition aspects that relate to
1:19.0	health performance and body composition so hopefully there'll be something in here for you that's
1:24.1	new that you learn something or allows you to develop your interest in certain
1:29.2	areas. I want to say a big thanks to everyone who sent in some feedback about last week's
1:34.8	episode with Mike T. Nelson on metabolic flexibility. Some really, really kind words about that one.
1:40.5	And I agree that Mike did an awesome job. So thank you for everyone who's been
1:44.5	sharing that on social media and tweeting about it and tagging people in Facebook. I always appreciate
1:50.1	that. As well as those are you leaving reviews for the show over on iTunes or on Stitcher.
1:55.5	So on this week's episode, I'm going to be talking with Dr. Brendan Egan from University College Dublin
2:02.4	here in Ireland, which was a privilege for me to get him on because over the past couple of
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