SNR #165: Kevin Hall, PhD - Testing the Carbohydrate-Insulin Model & a Response to Gary Taubes

Sigma Nutrition Radio

Danny Lennon

Nutrition, Health & Fitness

4.8 • 633 Ratings

🗓️ 14 February 2017

⏱️ 66 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode 165: Kevin Hall, PhD of the National Institutes of Health (NIH) is on the podcast to discuss his work examining the carbohydrate-insulin model of obesity and responds to recent comments on the issue by Gary Taubes.
Dr. Hall is a Senior Investigator in the Laboratory of Biological Modeling at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Kevin's laboratory investigates how metabolism and the brain adapt in response to a variety of interventions to diet and physical actvity. They perform experiments in both humans and rodents to better understand the complex mechanisms regulating macronutrient metabolism, body composition, and energy expenditure. A unique aspect of the laboratory involves the development of mathematical models to quantitatively describe, explain, integrate, and predict our experimental results.

Over the past couple of years, Kevin has been the principal investigator on a couple of high-profile metabolic ward studies looking to examine: 1) the effect of restricting calories from fat vs. from carbohydrates, and 2) the hypothesis that ketogenic diets offer a metabolic advantage.

In This Episode We Discuss:

Defining the carbohydrate-insulin model of obesity
Scientific models and the principle of experimental falsification
Main predictions of the carbohydrate-insulin model
Examining the idea that ketogenic diets confer a metabolic advantage
Response to recent comments from Gary Taubes
The effect of weight loss on appetite

Transcript

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0:00.0	And I don't think it would be accurate for me or anybody else to say that these results demonstrate that low-fat diets are superior in some way, because I don't believe that that's what these results show.
0:20.3	But they do show that at least the
0:23.3	articulation of the model of this carbohydrate insulin model is too simple. Whether or not that
0:31.4	happens to be true does not mean that carbs or insulin have nothing to do with obesity or low-carb diets can't be greatly beneficial for many people.
0:41.0	And I think that that's where a lot of people jump to that conclusion when you try to test a particular scientific model of obesity.
1:12.1	Yeah. Hello and welcome to episode 165 of Sigma Nutrition Radio.
1:15.0	As always, I am your host, Danny Lennon,
1:19.1	and you are very welcome to another episode of the podcast.
1:26.1	On today's show, I'm going to be talking with Dr. Kevin Hall of the National Institutes of Health,
1:29.5	who for you who are long-time listeners,
1:36.0	will remember he was back on the podcast way back in episode 88 when he discussed in detail one of his probably more infamous studies from 2015, the study that looked at restricting calories from carbohydrate versus restricting
1:48.5	calories from dietary fat and seeing what differences they had on body fat loss.
1:56.0	Again, that six-day study in a metabolic ward, which was again again, has been talked about extensively, particularly
2:02.4	online. We got into that in depth in that previous episode. And some of that still ties into
2:08.3	what we're going to discuss today because there's been even more developments and even more
2:12.9	interesting things to come from that. So just as a bit of background for those you who perhaps didn't hear
2:19.1	that and are unaware of Dr. Hall's background, he's a senior investigator in the laboratory
2:25.8	of biological modeling at the National Institute of Diabetes and Digestive and Kidney Disease,
2:31.4	again which comes on the umbrella of the NIH.
2:35.0	And his, the border, he investigates essentially how metabolism and then even the brain adapt in response to a variety of interventions to diet and physical activity.
2:48.0	So they use both human models as well as animal models to try and better understand
2:53.7	all these mechanisms that regulate macronutrient metabolism and body composition and energy
	...

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