SNR #164: Dominic D'Agostino, PhD - Press-Pulse Model of Cancer Therapy, Ketones & Metabolic Drugs

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 7 February 2017

⏱️ 72 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode 164: Dominic D'Agostino, PhD of the University of South Florida discusses his lab's research onto various treatment therapies for cancer including nutritional ketosis, hyperbaric oxygen therapy and metabolic drugs.
Dr. D'agostino is an Assistant Professor at the College Of Medicine Molecular Pharmacology & Physiology at the University of South Florida. The primary focus of his laboratory is developing and testing metabolic-based therapies, including ketogenic diets, ketone esters, ketone supplements and metabolic-based drugs. His research also explores the use of these metabolic therapies for a broad range of disorders linked pathophysiologically to metabolic dysregulation, including seizures, neurological disorders, wound healing, muscle wasting and cancer. The laboratory uses in vivo and in vitro techniques to understand the physiological, cellular and molecular mechanism of metabolic therapies.

In This Episode We Discuss:

Cancer as a metabolic disease
Potential mechanisms of action for ketosis being a beneficial metabolic state in cancer patients
Ketosis, calorie restriction, hyperbaric oxygen therapy and metabolic drugs as adjunct therapies in cancer treatment
Possible future avenues of research
What research needs to be done for this research to become seen more in front-line clinical practice
Barriers to implementation

Transcript

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0:00.0	We sort of know things already work from, so we test a lot of things from a top-down approach.
0:12.0	And that would involve dietary energy restriction to, you know, intermittent fasting or periodic feeding, ketogenic diet, ketone supplementation,
0:23.0	even hyperbaric oxygen, treatment, and various drugs that are dietary energy memetics.
0:30.2	And the overall goal here is kind of to put metabolic stress on the cancer,
0:41.1	and in addition to that to a pulse protocol that would periodically subject cancer to intense metabolic stress and also
0:47.1	oxidative stress. Hello and welcome to episode 164 of Sigma Nutrition Radio.
1:12.5	As always, I am your host, Danny Lennon, and thank you so much again for all of you
1:17.2	who continue to tune in to the podcast.
1:20.2	And maybe for some of you, if you are brand new to the podcast and this is your first episode
1:24.0	listening, then of course you are very welcome.
1:26.1	And hopefully you find not only plenty of information in this episode, but in all our previous episodes as well.
1:32.9	Just before we get started, again, a reminder, and I really kind of some just some words
1:37.5	of some, a big thank you to everyone who has purchased a Sigma weight cutting system for
1:42.9	MMA and boxing and who has contacted me
1:45.3	with some really positive feedback. I've got a number of emails and messages from those you
1:51.2	who have got it at this point who have said not only has it helped you in the immediate terms
1:57.4	who've had some fighters that have found immediate benefit. Those you are
2:01.3	coaching fighters or working on their nutrition with them and seeing some kind of new ideas
2:05.4	and some useful information. But some really nice words of people who kind of talked about how
2:10.9	they wish they would have had this information in the past and what benefit that might have
2:14.5	had. And like I think I mentioned previously, a lot of work went into it.
2:19.0	So to see that's having use means a great deal.
	...

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