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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Semaglutide (subQ) Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 29 December 2022

⏱️ 16 minutes

🧾️ Download transcript

Summary

On this podcast episode, I discuss the pharmacology, adverse effects, and drug interactions of semaglutide.



Semaglutide has two primary uses: Type 2 diabetes and Weight Management - the dosing varies depending upon the indication.



When using semaglutide, pay attention to GI adverse effects. Nausea, diarrhea, and vomiting are the most common ADRs and are dose-dependent.



Pay attention to corticosteroid bursts. They can cause substantial hyperglycemia and counteract the effects of diabetes medications like semaglutide.

Transcript

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0:00.0

Hey, all welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist,

0:04.5

Derek Christensen. Thank you so much for listening today. Go check out Real Life Pharmacology.com.

0:10.3

Get your free 31 page PDF on the top 200 drugs. Simply an email. We'll get you access to that.

0:16.2

I put that together personally a list of those top 200 drugs and obviously put in clinical practice

0:23.7

pearls as well as some of the most common things you're going to see on board exams and

0:28.3

pharmacology exams throughout your career. So definitely worth it. Simply an email. We'll get you

0:33.8

access to that and you can find that free PDF at real life pharmacology.com.

0:40.2

All right, let's get into the drug of the day today and that is semi-glutide.

0:46.2

Now, if you are a close listener to the podcast, you'll know that I've covered oral semaglutide previously,

0:53.6

particularly closer to when the drug initially came out.

0:57.4

But I wanted to spend some time on injectable semi-glutide because there are some differences

1:04.1

specifically with regard to the indication that it can be used for.

1:10.1

So the injectable semi-glutide, this is sub-Q injection given once a week.

1:15.5

You can inject it, abdominal area, thigh, upper arm.

1:19.7

So whatever's most comfortable, basically, for the patient.

1:24.0

In my experience, most are going to do the abdominal injection just for comfort sake.

1:29.6

It's usually the easiest and simplest and potentially least painful as well.

1:35.1

This is injectable semi-glutide brand name OZempic.

1:40.8

Now that is the brand name for the dosing that is entailed in type 2 diabetes management.

1:49.8

And then there's also a product called Wegovi, which is for weight management or weight loss.

1:57.6

So it is important to know with the indications, and this is one of the reasons why I kind of separated

2:04.4

semi-glutide, and I'm doing it again here.

...

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