Hey all, welcome back to the real-life pharmacology podcast. I'm your host, pharmacist,

is Derek Christensen. Thank you so much for listening today. Go to real-life pharmacology.com,

get your free 31-page PDF on the top 200 drugs. A great study guide, great refresher,

a great study tool. If you're taking pharmacology classes, board exams, absolutely a no-brainer

to go get that, simply an email. We'll get you access to that. All right, with that, let's get

into the drug of the day today. And that medication is methamazole. If you remember a few weeks ago,

I did propothia urosil, and these two medications are from the

same class of antithyroid medication. So why would we want to block thyroid hormone? Well, that's

probably pretty obvious if you've got a patient with hyperthyroidism.

Mechanistically, how does this drug work?

So ultimately, I think it's really important to remember T3, being one of the major thyroid

hormones, the most active thyroid hormone, and ultimately, methamazole is going to block the production of T3.

How it does that, it basically prevents iodine.

It prevents oxidation of iodine.

By doing that, that's a key player or a key role in the production formation of T3.

And so by blocking that process, ultimately you're going to block T3 formation.

Now, this is important to remember in the fact of a patient maybe with acute hyperthyroidism who's very symptomatic,

maybe they're a hospitalized patient, for example, in that methamazole doesn't touch circulating

T3-T-4. So again, that T-3 in the bloodstream, that's going to have the physiological action of thyroid hormone,

that's not going to be prevented or stopped by methamazole if it's already been produced.

What it's going to do, what the drug's going to do is prevent further production,

or at least reduce further production of T3 and ultimately bring down those levels. So it's,

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