Scientists Disrupt the Aging Game - James Peyer : 569
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 21 February 2019
⏱️ 72 minutes
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Summary
James Peyer is the founder and managing partner of Apollo Ventures, an early stage life science investment fund investing in Europe and the U.S. focused exclusively on breakthrough therapeutics arising from the study of the biology of aging. Apollo founds companies with scientists, invests in early stage therapeutics projects, and works with scientific teams to build biotech companies. The company invests in core technologies that show promise in reversing aging and extending human lifespan.
“My whole group thinks of ourselves as scientists first and investors second, and so we really get super, super excited about a specific mechanism of action or a cool new way to develop a drug or a way to target aging,” James says. “That's kind of the hook that brings us into a project much more than some of the traditional financial metrics.”
He also gives talks all over the world on the topic of aging, discussing how our newfound knowledge of what makes us age will enable the greatest medical breakthroughs of the 21st century.
In this episode of Bulletproof Radio, we talk about what venture capital has to do with aging and why it matters that deep investments are being made in the arena of longevity. We touch on bio-freedom, as well as how working intentionally within a system can persuade skeptics and change the world. We cover a lot of ground, including the population effects of longevity, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, altered intercellular communication, mitochondrial dysfunction and more.
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Transcript
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| 0:00.0 | You're listening to Bulletproof Radio with Dave Asprey. |
| 0:16.0 | Today's cool fact of the day is that if you're more than 100 years old, you're probably |
| 0:21.2 | biologically younger than your chronological age. |
| 0:25.1 | Some researchers at UCLA look at aging as a biological program written on your DNA and |
| 0:29.8 | they've seen evidence that there's a biological clock that marks milestones along your |
| 0:33.9 | life's path. |
| 0:35.8 | These guys are monitoring aging in mice by examining molecular tags called methyl |
| 0:40.3 | groups which attach to various locations on DNA in a process called methylation. |
| 0:45.3 | And if you've read any of my books like The Bulletproof Diet or Haswrong, I talk about |
| 0:49.3 | methylation and how about a third of us suck at methylating which will make you old |
| 0:54.0 | and inflamed unless you address it by taking the right forms of nutrients like 5MTHFR. |
| 0:59.9 | But if that was completely Greek to you, that's all right. |
| 1:02.8 | It's all over the Bulletproof blog. |
| 1:05.2 | Methylation is an epigenetic modification of your DNA and that's kind of like flagging |
| 1:10.0 | a passage in a book with sticky notes. |
| 1:12.3 | You attach a tag. |
| 1:14.0 | It doesn't change the information of the book. |
| 1:15.3 | It just draws a tense into those passages and tells you what you can skip the other pages. |
| 1:20.7 | These researchers at UCLA measured DNA methylation at 353 different spots in the human genetic |
| 1:27.2 | we'll call it instruction book or the genome. |
| 1:30.1 | And as we age, 193 locations accumulate tags kind of like when you see too many flyers |
| 1:37.1 | posted on a bulletin board. |
... |
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