Hey, all, welcome back to the Real Life Pharmacology podcast. I am your host pharmacist, Eric Christensen.

Thank you so much for listening today. As always, go to real life pharmacology.com. Get your free 31 page

PDF on the top 200 drugs. Great no-brainer. All it will cost you as an email. So go take advantage of that.

I lay out my most important points

with the top 200 drugs. So go do that, real-life pharmacology.com. With that, the drug of the day

today is Risperidone. Brand name is Risperdol. And this is a second generation antipsychotic.

And mechanistically, the main mechanism of pretty much all antipsychotics are dopamine

receptor blockade, and more specifically dopamine 2. You'll often hear it referred to as D2 receptor blockade.

With that said, mechanistically,

Resperidone does have some other mechanisms

that can lead to the adverse effect profile

and things of that nature.

So it does have some alpha blockade, so that can lead to hypotension potentially.

Histamine blockade it has as well, so it can have some anticholinergic activity.

And then there is some serotonin from 5H2 receptor antagonism as well.

All right.

So what do we use antipsychotics for?

I think that's pretty straightforward.

We're primarily going to see this medication used in schizophrenia or bipolar disorder.

Again, trying to treat some of those positive symptoms of

psychosis and schizophrenia, like hallucinations, for example.

So that's primarily what it's going to be used for.

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