Hey, all. Welcome back to the Real Life Pharmacology podcast. I'm your host,

pharmacist, Derek Christensen. Thank you so much for listening today. As always, go check out

real life pharmacology.com. Get your free 31 page PDF on the top 200 drugs. Great little

resource for you. Absolutely free. Just going to cost you an email and we give you updates as well when we

have new podcast episodes too. So go check that out. No brainer to snag that at real life pharmacology.com.

With that, let's get into the drug of the day today. And this is by request from an email I received.

And it's vortioxatine.

The brand name of this medication is Trintelix, and this medication as a general class is considered an antidepressant,

and that's pretty much in clinical practice the only thing I've ever seen it used for.

And probably more specifically, it's really historically been reserved for failure of, you know,

more traditional antidepressants, such as the commonly used generic SSRIs.

So you're, you know, sateloprams and Zoloffs and things of that nature.

So that's probably where you're going to see it as patients who failed numerous other

antidepressants and probably the biggest reason why that's the case, at least the time of this

podcast, this medication is a brand name medication, and so it's definitely

expensive and or you have to jump through insurance coverage hurdles in many situations as well.

So that's why its use is probably more limited, and if you're a practicing clinician,

probably why you haven't seen it a ton.

So with that said, I definitely have seen it used in clinical practice, usually by psychiatry.

And this medication does have kind of traditional SSRI activity.

With that said, it's also got some other activity on other serotonin receptors.

And the challenge with this and to know exactly how it all plays out is a lot of this is dose

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