RHR: Revisiting the Gut-Immune Axis
Revolution Health Radio
Chris Kresser
4.7 • 1.7K Ratings
🗓️ 12 May 2026
⏱️ 26 minutes
🧾️ Download transcript
Summary
The gut-immune axis is one of the most important and most overlooked systems in human health. In this episode of Revolution Health Radio, Chris explains how the gut microbiome, intestinal barrier, and immune system work together to regulate inflammation and protect against disease. Learn how disruptions in gut health, driven by ultra-processed foods, environmental toxins, antibiotics, and chronic stress, can lead to intestinal permeability, chronic immune activation, and a wide range of conditions including autoimmune disease, skin disorders, respiratory illness, and metabolic dysfunction. Chris also breaks down the latest research on key compounds that support gut and immune health, including probiotics, prebiotics, butyrate, polyphenols, colostrum, lactoferrin, and beta glucan. Discover how targeted nutrition and lifestyle strategies can restore gut integrity, improve immune resilience, and address the root cause of chronic illness.
The post RHR: Revisiting the Gut-Immune Axis appeared first on Chris Kresser.
Transcript
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| 0:00.0 | Chronic stress and poor sleep are at the root of so many health issues. |
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| 1:02.3 | steady spirit and take the first step toward going from wired and tired to calm and clear, |
| 1:07.2 | naturally from the inside out. Hey everybody, Chris Kresser here. |
| 1:11.4 | Welcome to another episode of Revolution Health Radio. |
| 1:14.2 | Over the last several years, immunity has become one of the most talked about topics in health. |
| 1:18.8 | COVID-19 forced most people to think seriously about their immune system for the first time, |
| 1:24.0 | and the conversation hasn't led up since. |
| 1:26.7 | Autoimmune disease rates are climbing. Allergies and |
| 1:29.3 | asthma affect record numbers. The recognition is growing that chronic illness is at its root |
| 1:35.0 | almost always an immune problem. Yet for all the attention immunity gets, the most important |
| 1:39.9 | piece of the puzzle is almost never discussed, either in mainstream medicine or in the broader |
| 1:44.1 | wellness conversation. That piece is the gut. Over my 15 years in clinical practice as a |
| 1:50.0 | functional medicine clinician, the gut immune axis, the dynamic bidirectional relationship between |
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