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The Curbsiders Internal Medicine Podcast

REBOOT: #462 Male Hypogonadism Pearls with Dr. Bradley Anawalt: Insights on Testosterone Deficiency

The Curbsiders Internal Medicine Podcast

The Curbsiders Internal Medicine Podcast

Education, Medicine, Higher Education, Science, Health & Fitness

4.83.3K Ratings

🗓️ 26 January 2026

⏱️ 92 minutes

🧾️ Download transcript

Summary

We have a classic episode for you. Master male hypogonadism diagnosis and management. Discover when and how to test, how to tackle confounding conditions, and why lifestyle changes may be more effective than testosterone therapy in certain patients. We are joined by Dr. Brad Anawalt, an expert in endocrine care, to guide us through the essentials.

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Show Segments

  • Intro
  • Case 1
  • History and Physical 
  • Laboratory Testing 
  • Effect of Lifestyle on Testosterone
  • Case 2
  • Prostate and Cardiovascular risk
  • Treatment Options and Considerations
  • Secondary Causes of Hypogonadism
  • Case 3
  • Testicular Size and Klinefelter Syndrome
  • hCG and Clomiphene
  • Monitoring and Follow-Up
  • Take-Home Points
  • Outro

Credits

  • Written and produced by Paul Wurtz MD. Show notes, cover art, and infographic also created by Paul Wurtz MD. 
  • Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP   
  • Reviewer: Sai S Achi MD, MBA, FACP
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Technical Production: PodPaste
  • Guest: Bradley D. Anawalt MD

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Transcript

Click on a timestamp to play from that location

0:00.0

Hey, listeners, you're about to hear a curbsiders classic episode.

0:03.5

If you heard it the first time, listen again for that space learning.

0:06.7

But if you haven't heard it yet, then you are in for a treat.

0:09.3

So without further ado, enjoy.

0:11.3

And don't forget to check out our Patreon at patreon.com slash curbsiders.

0:15.6

If you want ad-free episodes, bonus episodes, and a whole bunch of other cool stuff,

0:20.3

patreon.com slash curbsiders.

0:24.3

Hey, Paul, I started going to the gym in my tuxedo.

0:33.6

It's going to be, you're working on your formal, I can't make it work. I feel like formal got to be there. Let me tell you some more. Everything went well, Paul. I don't know. Everything went well except for the weightlifting. Do you know why? No. Because it wasn't my strong suit. It's not bad. Not bad. Yeah. The Curbsiders podcast is for entertainment, education, and information purposes only, and the topics discussed should not be used solely to diagnose, treat, cure, or prevent any diseases or conditions. For the more of the views and statements expressed on this podcast are solely those of the host and should not be interpreted to reflect official policy or position of any entity aside from possibly cash like more honest and affiliate outreach programs. If indeed, there are any, In fact, there are none. Pretty much, we are responsible if you screw up.

1:11.7

You should always do your own homework and let us know when we're wrong.

1:17.4

Welcome back to the curbsiders.

1:22.8

I'm Dr. Matthew Francoido here with my great friend, and America's primary care physician, maybe even,

1:30.0

probably even the primary care physician, Dr. Paul Nelson Williams. Hey, Paul. Hey, Matt. I like

1:37.2

that you're hedging on this a little bit more, which I think is the right thing to do. And,

1:41.5

yeah, I'm just trying to grow your legend.

1:49.5

Tonight we are going to revisit a, this was episode number one, Paul, testosterone.

1:52.0

We talked about testosterone and hypogonadism.

1:53.7

We thought it was time we update it.

2:02.7

This is with a great guest, Dr. Brad Anawalt, who we heard at ACP, and we knew we needed to talk more with him about this topic.

2:09.1

So before we introduce our co-host and tell you about Dr. Annawalt, Paul, would you remind people, what is that we do on curbsiders?

2:11.7

Yeah, but before I do, just to peek behind the curtain for audience, I actually tried to listen

2:15.0

to episode number one, which I had never listened to before in preparation for this, this episode in particular. And Matt, you sounded clinically depressed. I was genuinely worried about it just, it was a rough scene all the way around. It was not bad. I'm just saying that the show has certainly evolved in the, God, what, eight years that we've been doing it. So it's, for curious listeners, it's worth going all the way back to number one, which might only be available on our website just to kind of compare and contrast this episode to our very first one. Yeah, we probably didn't do enough practice episodes before we actually recorded our first episode. So it was, yeah, you know. And it featured my nemesis. You started out the gate with the great Dr. Jeff Colburn. The great Dr. Jeff Colburn.

...

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