QuANTUM - Quizartinib Front Line - Ethics of Global Trials

Plenary Session

Vinay Prasad, MD MPH

Policy, Medicine, Health, Oncology, Science & Medicine

4.8 • 798 Ratings

🗓️ 15 June 2022

⏱️ 42 minutes

🔗️ Recording | iTunes | RSS

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Summary

I discuss the timeline of Ratify and Quantum. Was this an ethical trial? Is it sufficient to say a trial is ethical because 50% of participants get something?

Transcript

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0:00.0	Welcome back to plenary session. These are the plenary session trial summaries.
0:05.0	I've got a good one today. I've got quantum first and we're going to talk about it
0:08.6	quesartnib in Flit 3 ITD, Frontline, AML. And really should be quantum second because it
0:15.7	ain't the first, it ain't the first drug to prove this. But before I get to that, I want a little
0:19.7	disclaimer about these videos.
0:21.1	I put out a series of videos in honor of ASCO on the YouTube channel and also on the Plenary Session
0:25.8	podcast feed. These break down these clinical trials, they get into the weeds. They range from
0:30.3	highly critical shine, what a piece of, what a terrible study, to highly laudatory dosterlamab.
0:36.4	And I've even had more conversations offline
0:38.5	about dostarlamab and people are really excited about it and i actually maybe i'm even more excited
0:43.1	about it going forward but today we're going to talk about quantum first if you are listening to the audio
0:48.3	feed i'm going to encourage you to go on the video feed for this the video feed i've got slides i've got visuals
0:53.6	it's going to be a lot
0:54.4	better experience for you. Look, I know what you're thinking. You prefer audio. Hey, I do too. I don't
1:00.1	like watching a lot of videos. I like audio. But for this clinical trial series, make an exception.
1:05.1	Go to the video feed. You're going to learn a lot more. And that's what this is, Plenary Session. Of course, a podcast that teaches you about oncology.
1:11.3	Let's talk about quantum first.
1:13.2	Quizart number frontline AML.
1:15.6	Over the course of this video, I'm going to argue that this trial is unethical.
1:18.5	It is unethical, of course.
1:19.7	It's in violation of the Declaration of Helsinki.
1:21.4	The control arm gets beneath the global best standard of care.
	...

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