Hey, all. Welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.

Thank you so much for listening today. Go check out Real Life Pharmacology.com. Get your free 31 page

PDF on the top 200 drugs. I just got an email from somebody thanking me for that. It's definitely a valuable resource, a good refresher if you've been out in practice or

if you're going through pharmacology classes. So in addition to that, I've got an exciting

new offer, flipping pharmacology flashcards. It is not quite out yet at the time of producing

this podcast, but a great resource, nearly 600 drugs covered

flash card format, excuse me. And yeah, I think it's going to be really, really helpful for

folks going through pharmacology classes or preparing for board exams. So with that, let's get into the drug of the day,

and that is Promethazine. Brand name of this medication is Fenergan. And mechanistically,

this drug is classified as an antihistamine and a dopamine blocking agent.

Another classification, it is considered a phenothiasein type medication.

In addition, so kind of leaning into the mechanism of action, so

antihistamine or H1 receptor blocking activity, that's what's thought to give its

anti-emetic type effects. And we'll talk about usages coming up here. Dopamine blocking activity,

that's going to be similar to antipsychotics and their mechanism of action.

So that can certainly play into the adverse effect profile, which I will discuss.

And then also mechanistically, it has some alpha blocking activities.

So this drug is an older drug.

And generally, when we think about some of the older medications,

they can sometimes be what we term as a little bit of a dirty drug

in that it does kind of multiple different things.

And the amount of activity regarding that mechanism of action

...