ProLivRx: How it Works
The Carlat Psychiatry Podcast
Pocket Psychiatry: A Carlat Podcast
4.7 • 524 Ratings
🗓️ 26 January 2026
⏱️ 13 minutes
🧾️ Download transcript
Summary
How a new FDA approved device for difficult-to-treat depression engages the brain through the sensory nerves in part II of our interview with Linda Carpenter.
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Published On: 01/26/2026
Duration: 12 minutes, 33 seconds
Chris Aiken, MD and Kellie Newsome, PMHNP have disclosed no relevant financial or other interests in any commercial companies pertaining to this educational activity.
Transcript
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| 0:00.0 | sensory deprivation. It sounds peaceful, relaxing at first, but it can get pretty depressing when |
| 0:07.8 | there's no input heading into the brain. And today, we'll find out what that means for the new |
| 0:13.2 | FDA-approved ProLiv RX. |
| 0:26.4 | Welcome to the Carlet Psychiatry podcast, keeping psychiatry honest since 2003. |
| 0:30.2 | I'm Chris Agen, the editor-in-chief of the Carlat Psychiatry Report. |
| 0:35.1 | And I'm Kelly Newsom, a psychiatric MP and a dedicated reader of every issue. |
| 0:48.4 | That's the sound of a pottery wheel, and it's just a taste of what you'd be feeling if your hands were coaxing the cool, soft clay as it spins in front of you. |
| 0:53.3 | But this study from 2017 will give us a better sense. |
| 0:57.5 | It took place in Hong Kong. Researchers randomized 106 patients with depression to a course in clay art, |
| 1:05.6 | pottery making, or a similar course in visual art. After three weeks, those who worked the clay with their hands saw improvements in depression. |
| 1:15.0 | The visual art group, not so much. |
| 1:17.8 | So what made the difference? |
| 1:20.0 | One possibility is the senses. |
| 1:22.6 | Think about touch. |
| 1:24.4 | Maybe you recall a story from your training about the harrowing way that doctor and nurses |
| 1:29.2 | discovered the power of touch. It was during World War II. Infants who had lost their parents |
| 1:35.1 | in the war were placed in orphanages. This was the antibiotic era, so the first thing on people's |
| 1:40.4 | minds was cleanliness, how to keep these babies free of infections. The goal was |
| 1:45.1 | achieved, but it came at a cost. Deprived of touch, the children failed to thrive. They regressed |
| 1:50.7 | in their development, withdrew, as if depressed. In what psychoanalyst Renee Spitz called |
| 1:56.7 | an anachlytic depression. We learned a lesson, and that's why we got out of our way to keep |
| 2:02.4 | babies stimulated a day, with touch and even massage. We decorate their rooms with spinning objects |
... |
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