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Hey, everyone, this is Dr. Rishio.

Let's discuss how probiotics can help prevent some of the negative effects from pPI or acid lowering medication use.

And I'd like to share with you the results of a study that I found very interesting.

I'll put the abstract up here on the screen. The study entitled Lactobacillus versus placebo for the prevention

of proton pump inhibitor induced irritable bowel syndrome or IBS, a randomized clinical trial.

And essentially, the setup of this study was looking at a group of patients who

were on pentoprasol, which is an acid-lowering PPI medication, and half of those subjects were

given a probiotic, and the other half were given a placebo. So this is the control group, and this is

the treatment group. The treatment got the probiotic and the placebo group was a control group.

And what they found was the use of a probiotic could prevent the following symptoms.

Bloading flatulence, stool form alterations that were negative and stool frequency that was negative.

And so this, of course, looks very much like IBS, and this study then concluded that lactobacillus supplementation prevents bowel symptoms onset in patients on long-term proton pump inhibitors.

So, again, they found that the use of probiotics prevent symptoms of IBS and in those on

acid lowering medication. So what may be happening here? Well, we do know, and I'll put another

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