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The Times Tech Podcast

Prellis Biologics’ Melanie Matheu: “Lab-grown kidneys"

The Times Tech Podcast

Will Morley

Business, Unknown, Technology

4.9654 Ratings

🗓️ 18 October 2019

⏱️ 42 minutes

🧾️ Download transcript

Summary

The Sunday Times’ tech correspondent brings on Merlanie Matheu, founder of Prellis Biologics, to talk about 3D-printing organs (2:15), cellular scaffolding (3:35), implanting lab-grown tumours in rats (5:15), why this is a big deal (6:35), solving the kidney (7:55), the magic of 3D printing (12:00), how she got into tissue engineering (13:45), filing a patent before knowing she could pull off the technology (18:10), the sector’s hype cycle (19:45), the future of organ printing (22:35), printing blood vessels first (25:20), why it was hard to raise money (29:35), getting regulatory approval (31:00), her worst day of work (35:00), creating the world’s first laser-based bio-printer (37:10), and where she gets the cells (40:05). 

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Transcript

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0:00.0

Yo, technology.

0:03.0

What is it all about?

0:04.5

So you can get it, right, you can basically give me a urine sample.

0:07.9

I'll give you a kidney.

0:09.4

Pretty close, yeah.

0:11.2

So it depends on how many times we can get those progenital cells to divide and scale them up.

0:16.0

Right.

0:16.5

But we wouldn't need probably more than like a week's worth of urine samples.

0:23.6

Hello and welcome back to Danny in the Valley, our first episode of the new season,

0:30.0

and we are starting with a bang.

0:33.2

A few weeks ago, I drove down to a little office park right on the waterfront in Hayward, California.

0:39.0

So I got to see the beautiful bay and a great big porta potty right in my line of sight.

0:45.1

But hey, you can't have everything.

0:47.3

Anyhow, I was visiting a little startup called Prellis Biologics.

0:52.3

And this is not your typical company. They grow blood vessels,

0:57.3

skin, and eventually entire organs in their lab. And I went to see it for myself.

1:06.0

Hi, Danny. Yeah. Aaron, nice to meet you. Come on in. Thank you. So we use some pretty high powered lasers. Don't be worried. Our guys know what they're doing. Yeah, this feels very robo cop. Yeah, I call them our doc. Punk. So what does that flash of light mean? What is happening? That's the actual laser being projected. And then these optics are basically

1:29.7

to relay the image that we form with the spatial light modulator. And we have a couple of

1:36.4

different... After my little tour of their laser printing lab, I sat down with Melanie Matthew,

1:46.4

Prelis's founder, to talk about what is actually happening in those four walls. And if she's successful, it would be kind of mind-blowing

1:53.5

for the pretty obvious reasons that replacement organs on demand would be.

2:01.2

We're live.

...

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