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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Phenobarbital Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 10 August 2023

⏱️ 15 minutes

🧾️ Download transcript

Summary

On this episode of the Real Life Pharmacology Podcast, I cover phenobarbital pharmacology, adverse effects, important drug interactions and much more.



Phenobarbital is an enzyme inducer. It is an inducer at CYP3A4 so this can lead to numerous drug interactions.



Phenobarbital can exacerbate the risk for opioid overdose and increase the risk for respiratory depression and death.



Phenobarbital can deplete numerous vitamins such as vitamin D, folic acid, and vitamin B12. Monitoring of these is important.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast.

0:03.4

I'm your host, pharmacist Derek Christensen,

0:05.4

and I thank you so much for listening today.

0:08.1

As always, go check out real-life pharmacology.com.

0:11.1

We've got a free 31-page PDF on the top 200 drugs.

0:14.9

It's a great study guide, great refresher,

0:17.4

no matter where you're at in your healthcare professional career. So again, real life pharmacology.com.

0:24.9

Same plain email is all it's going to caution. We get you updates when we've got new content out

0:30.1

available, like our flipping pharmacology flashcards or our pharmacology crossword puzzle book,

0:36.5

both on Amazon.

0:39.0

All right, let's get into the drug of the day today, and that is phenobarbital.

0:44.1

Brand name that I have heard most is luminal,

0:48.8

and this is an older anti-seizure medication or anti-epileptic medication.

0:57.0

Mechanistically, it is a barbiturate.

0:59.9

So it's going to basically depress the action of the brain in a general sense.

1:08.9

So sensory cortex, it's going to reduce motor activity, obviously cause

1:14.4

sedation. And ultimately, being an anti-seizure medication, that's what we're trying to do,

1:22.2

is to kind of blunt that activity and obviously reduce the incidence of seizures.

1:29.1

So that's the primary use.

1:31.4

It's not a drug that I see terribly often anymore.

1:35.2

It's a really, really dirty drug as far as drug interactions, things of that nature,

1:39.4

which I'll certainly get into.

...

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