Isotretinoin Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 3 August 2023

⏱️ 12 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

On this episode, I discuss isotretinoin pharmacology, side effects, drug interactions, and much more.

The iPLEDGE program is in place to ensure that pregnant patients do not receive this medication. I discuss this in more detail on this episode.

Sun sensitivity is an important adverse effect that patients should be aware of during seasons of high sun exposure.

Hepatic issues, myalgia, and psychiatric changes are rare adverse effects associated with isotretinoin.

Transcript

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0:00.0	Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host pharmacist, Eric Christensen.
0:05.5	Thank you so much for listening today. Go check out real life pharmacology.com. It's a no-brainer to get your
0:11.3	free 31-page PDF on the top 200 drugs. It's a great little study guide if you're in pharmacology
0:18.3	classes or taking board exams or if you just need a refresher
0:22.2	and you're out in clinical practice. So simply an email. We'll get you access to that. We get
0:27.1	you updates when we've got new podcasts available as well as other content. Like our two recent examples,
0:34.4	the flip and pharmacology flashcards on Amazon, as well as the pharmacology crossword
0:41.2	puzzle book available on Amazon as well.
0:44.7	All right, with that, let's get into the drug of the day today, and that is isotrentinone.
0:51.6	This medication is used for acne, It goes by the brand names of acutane and claryvus are the two most commonly used brand names I've seen. Acutane probably being the most common there. It is taken orally and obviously it has systemic absorption. It can be used
1:15.1	for acne I mentioned. It also can be used for certain types of skin cancers as well. I'm not
1:21.2	going to focus on that tremendous amount here because I've seen it mainly used for acne there.
1:29.7	Mechanistically, how does this drug work?
1:32.9	It actually reduces the sebaceous glands volume or size and ultimately reduces sebum production,
1:42.9	which if you remember, that is an important component in issues
1:47.6	with pimple formation and obviously acne development there.
1:53.3	Administration of this medication, most of the dosage forms are to be given, at least the standard dosage forms are to be given with food.
2:04.9	That does help absorption a little bit.
2:08.6	Also recommended can cause some mild esophagitis once in a while.
2:13.7	So it is recommended to give that with a full glass of water.
2:16.7	There are a couple dosage forms where it says it doesn't depend, you know, it doesn't matter whether you give it with food or not with food.
2:25.7	But most of the standard dosage forms are going to be with food, or at least you can get by with all of them with giving with food if you want to there.
	...

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