So you did a podcast with David Sinclair on your channel, right?

Before?

Yeah, a couple of years ago.

Okay.

So it was a while ago now because I would be curious if anyone's grilled them on the

Metformin study that just came out or like, like in general, did you talk to him about

his metformin use?

Because I know even before the study, you weren't like gung-ho on it to begin with.

So like your initial kind of like perspective of the drug, if it has viability in any

context would be, you know, just interesting for me to know personal interest.

And then above and beyond that this new data that came out that suggests it's like heavily implicated in the birth defects in males males yeah so hypospatius yeah we could

put a link or I can screen share I pulled some stuff up but yeah so I wasn't a fan of metformin

previously I'll enable the screen share let's's see. I'll contextualize this.

So metformin is a great example like we talked about.

Yes, here's a molecule somewhat derived from plants.

Again, there is a derivative of metformin in French lilacs, okay, which is essentially a

toxin.

This is a plant defense chemical.

Screen sure should be on now. Okay, cool. The mechanism,

I'll say this and then I'll pull up the study that we were talking about with hypospatius.

So the mechanism of metformin is super interesting. So people think that it's a complex one inhibitor,

but it doesn't inhibit complex one at physiologic concentrations. It actually does this.

...