is independent of APOE4 as far as strict cause and effect.

So it is not a causal factor.

Now, if there's a risk, you know, you say, oh, there's a risk.

Well, if you have family members, you know, associated with this,

it's just like with breast cancer, although that's much,

the familial breast cancer gene is actually more involved.

We know part of what it can do as a mechanism.

But, of course, now that we have Thomas Seifre's work, you know, there's other ways to manage that,

but I digress.

So that's the deal with the genetic markers.

As a matter of fact, there are no genetic markers

or a group of genetic markers

that would advance our understanding

of the mechanism of Alzheimer's

as far as I can see from the reports I've looked at.

Okay, so that's one thing.

The second thing is, what about what's involved with it?

Is there, you know, what kind of therapies, what kind of things, where have they been

focused?

I said they were working on this in 87.

Where has the focus been?

Well, it's been on the plaques.

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