Hello and welcome back to the zero to finals podcast.

I'm sorry for such a long delay, but the podcasts are back now and I'll be uploading

three times a week from now going forwards.

My name is Tom and in this episode I'm going to be going

through estrogen and progesterone. And you can find written notes on this topic at 0.0 to

finals.com slash estrogen and progesterone or in the zero to finals endocrine system book,

which is coming soon.

You can find flashcards and questions to train your knowledge and help you remember the information

for longer at members.0tofinals.com.

So let's get straight into it.

Estrogen and progesterone are the primary female sex hormones.

They are controlled by the hypothalamic, pituitary, gonadal axis, and they fluctuate during the menstrual cycle.

We're going to go through estrogen and progesterone, the hypothalamic pituitary gonadal axis,

female puberty, the menstrual cycle, female hypogonadism, polycystic ovarian syndrome,

hormonal contraception, menopause, hormone replacement therapy, and medications relating to estrogen and progesterone.

Let's start by talking about estrogen.

Estrogen is a steroid sex hormone mainly produced by the granulosa cells in the follicles in the ovaries in women.

The most prevalent and active version of estrogen is 17 beta estradiol.

Estrogen is also produced in smaller amounts by the adrenal glands, adipose or fat tissue,

which converts androgens to estrogen with the help of aromatase,

and in the testes in males, which again convert androgens to estrogen with the help of aromatase.

Let's go through some clinical relevance.

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