Oct 31 2025 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 31 October 2025
⏱️ 31 minutes
🧾️ Download transcript
Summary
Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial fibrillation are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Stable CAD Complete vs culprit-only revascularization at time of STEMI
- iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918
- PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520
- COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
- FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
- PCI Revascularization Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051
- CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261
- How a Meta-Analysis Can Mislead https://www.sensible-med.com/p/how-a-meta-analysis-can-misleadthe
II SEVERE Aortic Senosis
7-Year PARTNER 3 Results – TAVI vs SAVR
- 7-year results PARTNER 3 https://www.nejm.org/doi/full/10.1056/NEJMoa2509766
- PARTNER 3 at 1 year https://www.nejm.org/doi/10.1056/NEJMoa1814052
- PARTNER 3 at 5 years https://www.nejm.org/doi/10.1056/NEJMoa2307447
III Functional vs Anatomic Assessment in Suspected CAD
- 10-year follow-up of PROMISE trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2838118
- PROMISE Trial https://www.nejm.org/doi/10.1056/NEJMoa1415516
- CCTA vs Functional Stress Test – Meta-Analysis https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2655243
IV ARREST AF
- ARREST AF trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2840225
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Questions or feedback, please contact news@medscape.net
Transcript
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| 0:00.0 | You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology. |
| 0:05.7 | This podcast is intended for health care professionals only. |
| 0:08.8 | Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape. |
| 0:14.9 | Hi, everyone. |
| 0:16.2 | This is John Mandrola from the Heart.org Medscape Cardiology, and this is this week in Cardiology for |
| 0:22.6 | October 31st, 2025. This week, I'm discussing four pillars of cardiology, stable coronary |
| 0:30.9 | disease, severe aortic stenosis, the evaluation of chest pain, and the best therapies for patients with atrial fibrillation. |
| 0:39.3 | I'm going to start with a topic that seems specific but is not. |
| 0:44.3 | This is complete versus culprit-only revascularization at the time of stemmy. |
| 0:50.3 | When a patient presents to the cath lab during a stemmy, there is often a decision to make, |
| 0:55.2 | when there are other lesions besides the culprit lesion. |
| 0:59.1 | Say the right coronary artery is closed and that's causing the MI. |
| 1:02.7 | The doctor opens that one, but there is an 80% mid-LAD. |
| 1:06.4 | Does she or he also PCI, the non-culperate LAD lesion? |
| 1:11.6 | Again, you might think this is esoteric just for interventional cardiologist. |
| 1:15.6 | It's not. |
| 1:16.9 | It's a hugely important question for the field of coronary artery disease. |
| 1:21.1 | And here is why. |
| 1:23.3 | Nearly every trial of PCI added to medical therapy versus medical therapy alone in patients |
| 1:29.6 | who have stable CAD, courage, Barry 2D, scheming trials, have all found no added benefit |
| 1:36.9 | to routine or initial PCI over medical therapy. |
| 1:40.7 | Yet the guidelines regarding complete versus culprit-only PCI at the time of STEMI suggest benefit from complete revascularization. |
... |
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