Niacinamide Found to Reduce the Risk of New Skin Cancers
Dr. Joseph Mercola - Take Control of Your Health
Briana Mercola
4.6 • 1.5K Ratings
🗓️ 22 November 2025
⏱️ 8 minutes
🧾️ Download transcript
Summary
- Skin cancer affects one in five Americans, with nonmelanoma types like basal and squamous cell carcinoma making up most cases. Niacinamide, a form of vitamin B3, is found to offer a strong preventive effect
- A recent study published in JAMA Dermatology associated niacinamide use with a 14% lower overall risk of developing additional nonmelanoma skin cancers, with the greatest benefit seen after the first cancer diagnosis
- Earlier research showed that taking 500 milligrams of niacinamide twice daily reduced new nonmelanoma skin cancers by 23% and precancerous lesions by up to 15%
- Niacinamide protects your skin by restoring NAD+ for DNA repair, reducing inflammation, supporting immune defenses, and strengthening the barrier that maintains moisture and resilience against environmental stress
- For long-term use, smaller daily doses of 50 milligrams three times per day are safe and sustainable. Combining niacinamide with sensible sun exposure habits and good nutrition strengthens skin defense naturally
Transcript
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| 0:00.0 | What if a simple form of vitamin B3 could lower your odds of a repeat skin cancer without side effects or complicated routines? |
| 0:08.0 | Welcome to Dr. Mercola's cellular wisdom. Stay informed with quick, easy-to-listen summaries of our latest articles, perfect for when you're on the go. No reading required. |
| 0:18.0 | Subscribe for free at Mercola.com for the latest health insights. |
| 0:22.3 | Hello and welcome to Dr. Mercola's cellular wisdom. I'm Ethan Foster, and today we're looking |
| 0:27.6 | at niacinamide, a well-studied, accessible nutrient, with growing evidence that it helps you |
| 0:32.7 | reduce the risk of new non-melanoma skin cancers while supporting day-to-day skin repair. I'm Alara Sky. |
| 0:39.8 | Skin cancer touches one in five Americans, with basal and squamous cell carcinomas making up the |
| 0:45.3 | vast majority of cases. Recurrence is common, which is why the data around niacinamide are important. |
| 0:52.3 | Used appropriately, it's been linked to fewer new cancers |
| 0:55.6 | and fewer precancerous lesions. Niacinamide is a form of vitamin B3 that does not cause flushing. Inside |
| 1:03.3 | your cells, it restores NAD plus, the coenzyme that powers energy production, DNA repair, |
| 1:10.1 | inflammation control, and mitochondrial function. |
| 1:13.6 | When UV exposure or aging depletes NAD Plus, your repair system slow. |
| 1:19.6 | Niacinamide helps replenish that supply, so your skin maintains normal surveillance and recovery. |
| 1:25.6 | You recycle niacinamide through the NAD plus salvage pathway, |
| 1:29.9 | converting it to NMN and back to NAD plus, |
| 1:33.9 | so repair enzymes like PARPS and Sertuans have the fuel to fix DNA strand breaks. |
| 1:40.3 | This is one reason dermatologists have used niacinamide in topical and oral forms for concerns |
| 1:46.7 | like acne, rosacea, uneven pigmentation, and photo aging. A recent retrospective study published |
| 1:54.5 | in JAMA dermatology analyzed 33,822 veterans, and found that niacinamide use was associated with a 14% lower overall risk |
| 2:04.6 | of developing additional non-melanoma skin cancers. The benefit was greatest when people started |
| 2:10.4 | after their first cancer diagnosis, where the reduction reached 54%, with the strongest effect |
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