Neuroscientist Emily McDonald: #1 Science-Based Hack to Rewire Your Brain to ACTUALLY Manifest the Life You Want
On Purpose with Jay Shetty
iHeartPodcasts
4.8 • 28.5K Ratings
🗓️ 3 November 2025
⏱️ 90 minutes
🧾️ Download transcript
Summary
Do you believe the brain can be trained to manifest?
Do you think it’s more about mindset or action?
Today, Jay sits down with neuroscientist and creator Emily McDonald to explore how rewiring your brain can transform every area of your life. Emily shares how understanding the science behind your thoughts, emotions, and behaviors can help you break free from cycles of fear, self-doubt, and procrastination. She explains that the brain’s natural instinct is to keep you safe, not help you grow, which is why so many people feel stuck even when they’re trying to move forward. Through relatable examples and neuroscience-backed tools, Emily reveals how awareness, intention, and identity shifts can create real and lasting change.
Jay and Emily dive into the psychology of motivation, discussing why we often delay the things we care about most and how “cheap dopamine” from social media and instant gratification keeps us from deeper fulfillment. Emily explains how to retrain your brain to crave long-term rewards, not quick hits of pleasure, and how to use self-compassion and small wins to build momentum. Together, she and Jay unpack the science of manifestation, why it’s not about wishing for things to happen but about wiring your brain to become a match for the life you want.
In this interview, you'll learn:
How to Rewire Your Brain for Change
How to Break Free from Feeling Stuck
How to Overcome Fear of Success
How to Stop Relying on Cheap Dopamine
How to Build Motivation Through Self-Reward
How to Attract Healthy Love by Becoming a Match for It
True transformation doesn’t happen overnight, it begins the moment you decide to understand yourself more deeply. When you learn how your mind works, you realize that every setback, fear, and doubt isn’t a failure, it’s simply your brain trying to protect you.
With Love and Gratitude,
Jay Shetty
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What We Discuss:
00:00 Intro
01:00 Relationships Begin with Intention
02:39 When Your Identity Keeps You Stuck
05:42 The Power of the Labels You Use
08:17 Are You Afraid of Being Seen?
10:08 Label the Fears Holding You Back
12:12 Play Out Every Fear to the End
13:48 Stop Chasing Cheap Dopamine!
17:31 3 Ways to Naturally Boost Dopamine
22:29 The Power of Having Something to Look Forward To
25:22 The Mindset Shift That Changes Everything
27:00 Why Desperation Blocks Success
31:29 Discovering Your Deepest Core Value
32:56 The Power of Understanding Your Own Brain
39:41 Surround Yourself with Expansive Minds
43:07 The 3-Step Science Backed Manifestation Tool
47:39 Do You Believe in Divine Timing?
49:09 Turning Jealousy into Inspiration
51:51 Worthiness Begins with Self-Love
56:13 How to Overcome Limiting Beliefs
01:02:14 What Are You Building Within Yourself?
01:04:19 Let Go of the Need for Approval
01:09:53 Love Finds You When You Least Expect It
01:15:51 Emily on Final Five
Episode Resources:
Emily McDonald | Website
Emily McDonald | YouTube
Emily McDonald | Instagram
Emily McDonald | TikTok
Emily McDonald | LinkedIn
See omnystudio.com/listener for privacy information.
Transcript
Click on a timestamp to play from that location
| 0:00.0 | This is an IHeart podcast. |
| 0:04.0 | The big reason why a lot of people stay stuck is that we are actually subconsciously |
| 0:08.7 | afraid of what it might look like if we succeed at doing it. |
| 0:12.5 | Get specific about your goals, but get specific about your fears. |
| 0:16.7 | Hey everyone. |
| 0:17.3 | Welcome back to On Purpose, the place you come to listen, learn and grow and become |
| 0:21.6 | happier, healthier and more healed. Today's guest is Emily McDonald, neuroscientist and |
| 0:27.6 | founder of Mindcraft, neuroscience-backed tools to rewire your brain and master your reality. |
| 0:34.1 | Emily shares how understanding the brain can help you break free from limiting patterns, |
| 0:39.3 | manage your emotions more effectively, and consciously create the life you want. |
| 0:44.3 | This conversation will help you see how real change starts from within and how rewiring |
| 0:49.8 | your brain can transform your reality. |
| 0:53.0 | Please welcome to On Purpose, Emily McDonald. Emily, it's great to have you here. It's so amazing to be here. Thank you for having me. I love following you on social media. I feel like I learned so much. I have so many friends who live and swear by your page. And so to have you here now is awesome. And again, congratulations on all your success. I know you just got |
| 1:10.9 | engaged as well. So thank you. Congratulations on that. It was wonderful to meet your fiancé. |
| 1:14.9 | Yep, yep. But let's dive straight in. If someone was to listen to our conversation today and apply the |
| 1:23.0 | things you have to say, how would their life change? I'd like to say that it can and will change in every single aspect that you apply it to. |
| 1:34.0 | I think that, and you know, actually one of my students in Minecraft, she joined a few months |
| 1:39.2 | ago and I asked her, I said, in which ways do you think that your life has changed since |
| 1:43.9 | joining? And she said every single aspect of her life in which ways do you think that your life has changed since joining? |
| 1:44.3 | And she said every single aspect of her life has changed. And I think that the principles that I teach and I coach on and that I practice, I think they really can be applied to every single area of your life. |
| 1:56.8 | So, yeah, I think it just depends on you and what you choose and what you intend, right? So it's all |
| 2:02.1 | about intention there. And it's like if you want to apply it to relationships, you can. But also, |
... |
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