Hi, this is Tom, and in this episode I'm going to be going through Neonatal Sepsis,

and you can find written notes at 0.0.5.com slash neonatal sepsis, and in the 0 to Finals

Pediatrics book. And you can find flashcards and questions at members.0.0.5.com.

So let's jump straight in. Neonatal sepsis is caused by infection within the first 28 days of life.

Early onset neonatal sepsis occurs within 72 hours of birth.

It features high morbidity and mortality for the affected infant, particularly if treatment is delayed.

The signs are non-specific and a high degree of suspicion and a low threshold for starting treatment is

required. Refer to policies and guidelines and involve seniors when treating patients.

Let's start by talking about the causative organisms.

The most common organisms associated with neonatal sepsis include

Group B Streptococcus, or GBS, which is transmitted from the mother's vagina,

Escherichia coli, or E. coli, lysteria, which is often associated with contaminated food

consumed by the mother, for example unpasturized dairy products, Klebsiella, which is often

associated with hospital environments, for example the neonatal

intensive care unit, and Staphylococcus aureus, which is also often associated with

hospital environments.

A tom tip for you, remember Group B Strep, or GBS, for your exams.

This is a common bacteria living harmlessly in the vagina.

It can be transferred to the baby during labour and cause neonatal sepsis.

If the mother is found to have Group B strep in their vagina during pregnancy, prophylactic

antibiotics are given during labour to reduce the chances of transfer to the baby.

Let's talk about the risk factors.

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