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Nature Podcast

Nature Podcast: 24 March 2016

Nature Podcast

podcast@nature.com

Science, Technology, News

4.5893 Ratings

🗓️ 23 March 2016

⏱️ 31 minutes

🧾️ Download transcript

Summary

This week, toggling brain activity with radio waves, how to build stuff that lasts, and making thrillseekers into care-takers.

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Transcript

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0:00.0

This week, the brain cells that make some rats thrill-seekers and others overcautious.

0:07.8

We could instantaneously convert them from risk-seeking to risk-averse.

0:12.6

And how to go from make-use dispose to make-use repair reuse.

0:18.3

Whatever I have, I try to figure out how long I can use it. And that's why I've

0:24.5

kept my first car from 1969, and I'm still driving it. Plus using magnets and radio waves to control

0:31.6

the activity of an animal's cells. In some of the studies we published earlier, we could just change the activity of a gene by literally

0:40.1

waving a magnet that was bought at a hardware store over the liver of an animal.

0:44.4

This is the nature podcast for March the 24th, 2016.

0:48.6

I'm Adam Levy.

0:49.6

And I'm Kerry Smith.

0:53.8

Scientists have known for a long time that changing the electrical activity of brain cells

0:58.6

affects their function. That's why electroshock therapy is still used to treat a range

1:03.2

of psychiatric disorders. But over the years we've got better and better at controlling

1:08.2

the electrical activity of specific regions of the brain.

1:12.1

To treat diseases like Parkinson's, for example, an electrode can be implanted to stimulate neurons

1:17.8

in a part of the brain. But the problem with methods like these is that they require permanent

1:22.9

implant in the brain, which is very invasive. Wouldn't it be great if you could just turn cells on and off with just a radio wave or a magnet?

1:32.2

Well, Jeffrey Friedman and collaborators at Rockefeller University in New York definitely thought so.

1:37.7

I called Jeffrey up to find out about their new approach.

1:41.2

So we've developed a method that allows you to control the activity of nerve cells

1:47.4

and other cells now using a magnetic field. The system takes advantage of two different components.

1:54.3

The first component is a channel known as TriPV1. TriPV1 is a receptor in your tongue and also nerve cells that

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