4.8 • 1.2K Ratings
🗓️ 10 March 2023
⏱️ 12 minutes
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Several new studies find NAC and Glycine combinations can support biologic aging and more. Let's dive into these details.
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Studies and detailed show notes: https://bit.ly/41YvaMv
Episode Time Stamps
00:00 Glutathione is one of your body’s most important antioxidant and detox molecules.
00:30 Supplement with raw materials, instead of directly supplementing with glutathione.
01:00 N-acetylcysteine and glycine are rate limiting amino acids in glutathione production.
01:00 Glutathione is comprised of glutamine, cystine, and glycine.
02:40 Glycine-NAC supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, ageing hallmarks, metabolic defects, muscle strength, cognitive decline and body composition.
05:20 Taking direct antioxidants has conflicting evidence.
07:30 GGT liver enzyme is a marker of glutathione turnover.
11:00 Take antioxidant supplements in the evening.
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| 0:00.0 | Glutathione is one of your body's most important antioxidant and detoxification molecules. |
| 0:04.3 | Unfortunately, many people actually have a deficiency in glutathione. |
| 0:07.0 | We're going to talk about ways to simply assess and measure potentially your need for glutathione |
| 0:11.8 | support. |
| 0:12.8 | And the conditions that are linked with glutathione insufficiency such as mitochondrial |
| 0:16.2 | function, accelerated aging, and increased markers of oxidative stress that are linked |
| 0:20.6 | with all sorts of conditions that are common, unfortunately, like prediabetes, diabetes, |
| 0:25.0 | heart disease, even certain forms of cancer, and neurodegenerative conditions are characterized |
| 0:29.9 | by insufficient glutathione levels. |
| 0:31.9 | Now many people are supplementing with direct glutathione. |
| 0:35.2 | Now that might not be optimal because your body's balance of oxidative versus redox stress |
| 0:40.6 | is actually quite sensitive and specific. |
| 0:42.5 | So scientific researchers are actually highlighting the importance of, instead of supplementing |
| 0:46.9 | directly with glutathione to help support glutathione levels, you should allow your body and |
| 0:52.5 | yourselves to auto-regulate their glutathione synthesis by providing the two rate limiting |
| 0:57.1 | amino acids for glutathione production. |
| 0:59.2 | That is, enacetylcystine and glycine. |
| 1:02.5 | I think a lot of people forget about glycine, but if you look here, you can see how the |
| 1:07.2 | glutathione tripeptide is comprised of glutamine, which is widely abundant in your body, in your |
| 1:12.6 | diet, and so forth. |
| 1:14.0 | What is not so abundant is actually cystine, and that's why people supplement with enacetylcystine |
| 1:19.8 | as well as glycine. |
... |
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