4.8 • 1.2K Ratings
🗓️ 15 March 2023
⏱️ 18 minutes
🧾️ Download transcript
Let's discuss how how different macronutrients and blood sugar issues can regulate aging and the induction of cellular senescence. We also discuss how various dietary interventions can achieve prevention of disease and extension of lifespan by modulating senescence.
Sponsored Message:
Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE:
Use code podcast to save 12%
Link to Articles & Images: https://bit.ly/42kjEen
Show Notes:
00:25 Cellular senescence accelerates biologic ageing.
02:00 Senescent cells are enlarged, have dysfunctional mitochondria, and release pro-inflammatory signaling molecules.
02:30 Senescence manifests as wrinkles, memory loss, muscle loss, gray hair, fatty liver, excessive visceral adipose tissue.
03:45 Senescence occurs in response to stressors or developmental signals and behave similar to cancer cells.
05:45 Dysfunctional mitochondria influences glycolysis in cells.
06:15 Give your cells less fuel, glucose, for the proliferation of inflammation.
07:45 Hyperglycemia decreases nitric oxide, which helps prevent cellular senescence.
08:00 Sirtuins can inhibit the formation of senescent cells.
08:55 Berberine, Metformin, and low dose rapamycin, have been used to mitigate hyperglycemia.
10:30 Hyperglycemia also impacts your cardiovascular system and endothelial cells.
12:00 Fat cells can become senescent.
13:00 Ketones (BHB) can help inhibit cellular senescence.
13:25 Optimized omega 3 to omega 6 ratio can help.
14:00 Exercise counters age-related accumulation of senescent cells.
14:40 Senescence within your immune cells is linked with cancer and poor response to infection.
Click on a timestamp to play from that location
| 0:00.0 | Let's talk more about how blood sugar levels impact your body's aging response. |
| 0:03.6 | I think this is really important for a lot of people as you approach 40, 50, 60. |
| 0:07.4 | You care about how you look, how you age, texture of your skin, wrinkles, gray hair versus not gray |
| 0:12.5 | hair. In today's show, we're going to talk more about this connection and specifically focus in |
| 0:16.5 | on why blood sugar control and maintaining normal blood sugar levels is so important to the |
| 0:21.7 | mechanisms of aging. We're going to talk about a key process known as cellular senescence. |
| 0:26.5 | Essentially, what happens is your cells, as they become more dysfunctional, |
| 0:30.4 | metabolically speaking, they can enter a state of senescence, which is characterized |
| 0:34.8 | by inflammation. The senescent cells start to recruit other cells in your body to behave |
| 0:40.1 | abertally and senescent like. This accelerates biologic aging. We're going to really focus in on |
| 0:46.1 | how glucose, namely hyperglycemia and glycemic variability, how it impacts this critically |
| 0:52.2 | important cellular process known as senescence and may foster or favor cells to enter into this |
| 0:58.9 | senescent state. I would like to first define what cellular senescence is and talk more about that |
| 1:03.7 | and then we'll talk specifically about how hyperglycemia and aberrant levels in blood sugar, |
| 1:09.0 | variability, and variation can actually foster the formation or transition from a normal cell |
| 1:15.6 | into a senescent cell. As you can see here in the paper in free radical biology and medicine, |
| 1:21.1 | the title of this paper is synolytics and synamorphics. By the way, synolytics and synamorphics |
| 1:26.4 | are therapeutic mechanisms that we can impart on our body to decrease the propensity or the |
| 1:33.2 | accumulation of these senescent cells. There's all sorts of things from resveratrol to |
| 1:37.9 | quercetin, to curcumin, to intermittent fasting, to exercise that we're going to talk about today, |
| 1:44.1 | but there is a category of medicine or drugs, longevity enhancing drugs known as synolytics |
| 1:49.6 | and synamorphics that can help accelerate this process, just so you understand. So what you see in |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Mike Mutzel, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Mike Mutzel and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2025.