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The Dr. Hyman Show

Millions of Women Stopped Taking Hormones Because of a Misread Study | Dr. Sharon Malone

The Dr. Hyman Show

Dr. Mark Hyman

Medicine, Health & Fitness, Nutrition

4.59.1K Ratings

🗓️ 27 May 2026

⏱️ 87 minutes

🧾️ Download transcript

Summary

For far too long, many women have been told their symptoms were normal, exaggerated, or simply something they had to live with—treated as isolated problems instead of part of a much larger hormonal transition happening inside the body. On this episode of The Dr. Hyman Show, I’m joined by Dr. Sharon Malone, host of The Second Opinion podcast and Chief Medical Advisor at Alloy Women’s Health. We discuss how menopause and hormone therapy became so misunderstood, the real story behind the Women’s Health Initiative study, and why a more individualized, prevention-focused approach to women’s health is long overdue. Watch the full conversation on YouTube, or listen wherever you get your podcasts. We explore: Why so many women enter perimenopause completely unprepared—and how symptoms can begin years before menopause officially starts What the Women’s Health Initiative actually found, and how one medical narrative reshaped women’s healthcare for decades How menopause affects far more than reproduction, including the brain, heart, sleep, metabolism, and bone health What you should know about hormone therapy today, including timing, individualized treatment, and understanding risk in context The daily habits that still matter most for healthy aging, whether or not you choose hormone therapy Midlife health should never be reduced to “just deal with it.” The more women understand what’s happening inside their bodies, the earlier they can take steps to protect their long-term health and quality of life. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health - ⁠Click Here⁠ Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Paleovalley, Pique, Perfect Amino, Rho, Sunlighten and BIOptimizers. Head to paleovalley.com/hyman to save 15% off your first order today. Secure 20% off your order plus a free starter kit at piquelife.com/hyman. Go to bodyhealth.com and use code HYMAN20 to get 20% off your first order. Head over to rhonutrition.com and use code HYMAN to get 20% off their entire product line. Visit sunlighten.com and use code HYMAN to save up to $1600 today! Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. (0:00) Introduction, survey on hormone use, and Dr. Sharon Malone’s expertise   (4:04) Importance of women's health research and historical neglect   (5:35) Lack of education and preparation for menopause   (6:28) Societal and historical biases in women's health   (9:05) Observational studies vs. randomized controlled trials   (13:30) Life cycles, hormonal changes, and stages in women   (19:26) Detailed stages of hormonal changes and perimenopause   (23:00) Misdiagnosis and definition of menopause   (25:02) The term "postmenopausal" and its significance   (26:34) Impact of menopause on organ systems and major symptoms   (31:19) Lifestyle factors and hormone therapy options   (39:25) Black box warning, Women’s Health Initiative, and therapy timing   (45:00) Women's Health Initiative findings and breast cancer risk   (47:57) Reinterpreting breast cancer risk and black box warning   (53:21) Personalized hormone therapy and clinical diagnosis   (59:55) Importance of estrogen and bioidentical vs. synthetic hormones   (1:03:35) Addressing sexual health and testosterone use for women   (1:08:05) FDA-approved peptides for women’s arousal disorder   (1:09:57) Long-term benefits of hormone therapy   (1:12:43) Early menopause, hormone therapy, and health impacts   (1:15:07) Estrogen’s role in brain health and dementia prevention   (1:16:22) Alzheimer’s risk in women and hormonal

Transcript

Click on a timestamp to play from that location

0:00.0

What if brain fog, anxiety, and mood swings aren't simply all in your head?

0:04.7

What if the health of your mind actually starts deeper in your body, in your gut,

0:09.7

and your hormones, metabolism, and your immune system?

0:12.3

Well, let me tell you, the connection is real, and it affects how you think and you feel

0:16.4

every single day.

0:17.3

And that's why I created Brain Shaping Academy, a six-week program that shows you how

0:22.1

healing your body can help you heal your mind. Brain Shaping Academy relies on the same targeted

0:27.6

nutrition and lifestyle strategies that I've used for 30 years to help my patients improve their

0:31.9

mental, emotional, and cognitive health. So if you want to feel calmer, clear, and more in control,

0:37.4

and stay sharp and

0:38.3

protect your brain as you age, check out Brain Shaping Academy at Dr.hyman.com or slash brain shaping.

0:45.0

That's Dr.heimen.com or slash brain shaping. When women need to start thinking about hormone

0:50.6

therapy, can you help us frame how they should start thinking about it? The thing that maybe we should just unpack is this black box warning that came from the FDA

0:58.2

because it's what got people really scared.

1:00.1

So the black box warning for hormone therapy was what?

1:02.9

It will increase your risk of heart attack, of stroke, of dementia, breast cancer.

1:09.3

You can't apply that same data from 79-year-olds and 65-year-olds to 45-year-olds.

1:15.4

They're not the same.

1:16.1

Overnight, I think 50 million women stopped hormones,

1:18.9

which created a catastrophe in the country.

1:22.7

So let's talk about that.

1:23.7

There's a survey that found that 66% of women really are completely unprepared.

...

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