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The Dr. Hyman Show

Is HRT Safe? 10 Questions Women Ask Most — Answered by a Functional MD

The Dr. Hyman Show

Dr. Mark Hyman

Medicine, Health & Fitness, Nutrition

4.59.1K Ratings

🗓️ 25 May 2026

⏱️ 46 minutes

🧾️ Download transcript

Summary

Hormone replacement therapy is one of the most talked about—and misunderstood—topics in women’s health. For years, women were told HRT was dangerous. Now, the conversation is shifting, but many are still left confused about what’s actually safe, when to start, and whether hormones are even right for them. In today’s episode, I’m joined by Dr. Cindy Geyer from my clinic, The UltraWellness Center, to answer the most common questions we received from our audience about hormone replacement therapy, including: What the latest research actually says about the safety of HRT—including breast cancer and cardiovascular risk Why timing matters and the critical “window of opportunity” around perimenopause and menopause The difference between bioidentical hormones, synthetic hormones, compounded options, and patches vs. oral therapy How hormones impact sleep, brain fog, weight distribution, insulin resistance, libido, bone health, and healthy aging Natural strategies that can support hormone balance alongside—or without—HRT, including nutrition, exercise, stress reduction, and targeted supplements How functional medicine personalizes hormone therapy through testing, estrogen metabolism, gut health, genetics, and lifestyle factors Menopause is not just a hormone issue—it’s a full-body metabolic transition. And hormone therapy isn’t one-size-fits-all. The key is understanding your biology, your symptoms, and your long-term health goals so you can make informed decisions that support vitality, resilience, and healthy aging. Visit ⁠functionhealth.com for 160+ lab tests at just $365 a year. Want more on brain health? Sign up for the Brain Shaping Academy HERE. Have a question you’d love answered on Office Hours? Submit it here As a special thank you for our listeners, we’re offering $300 off a Functional Medicine Consultation Package, the most comprehensive service offering at Dr. Hyman's Functional Medicine Clinic, The UltraWellness Center. To learn more and book your consultation, please schedule a New Patient Discovery Call at the link HERE and reference the Dr. Hyman Show. Disclaimer: Offer expires July 31, 2026. Functional Medicine Consultation Appointments must be booked by July 31,2026 but may take place at a later date. The initial call with a New Patient Engagement Coordinator is required to book the appointment. Offer not valid on other appointment types or existing appointments. Offer valid for bookings with Dr. Boham, Dr. Geyer, Dr. LePine and Dr. Papanicolaou. (0:00) Welcome, introduction, and overview of hormone replacement therapy (1:26) Introduction of Dr. Cindy Geyer and safety of HRT (4:13) Timing, risks, and cancer concerns with HRT (7:06) Functional medicine perspective and factors in starting HRT (12:10) Benefits, timing, and natural alternatives to HRT (16:33) Prescription, bioidentical, and compounded hormones (19:20) Symptoms improved by HRT and libido considerations (22:24) Vaginal estrogen, progesterone, and recognizing need for therapy (24:25) Health markers and types of hormone testing (27:08) Duration, contraindications, and tailored hormone therapy (33:34) Preview: Dr. Sharon Malone on breast cancer risk (42:24) Introduction and details of Brain Shaping Academy

Transcript

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0:00.0

What if brain fog, anxiety, and mood swings aren't simply all in your head?

0:04.7

What if the health of your mind actually starts deeper in your body, in your gut,

0:09.7

and your hormones, metabolism, and your immune system?

0:12.3

Well, let me tell you, the connection is real, and it affects how you think and you feel

0:16.4

every single day.

0:17.3

And that's why I created Brain Shaping Academy, a six-week program that shows you how

0:22.1

healing your body can help you heal your mind. Brain Shaping Academy relies on the same targeted

0:27.6

nutrition and lifestyle strategies that I've used for 30 years to help my patients improve their

0:31.9

mental, emotional, and cognitive health. So if you want to feel calmer, clear, and more in control,

0:38.3

and stay sharp and protect your brain as you age, check out Brain Shaping Academy at Dr.hyman.com for slash brain shaping.

0:45.0

That's Dr.heimen.com or slash brain shaping. Welcome to office hours.

1:02.3

This is our dedicated one-on-one space to go deeper, get clear, and explore what truly moves the needle for your health.

1:07.7

I'm Dr. Mark Hyman, and each week we're going to pull back the curtain and share the insights, the research, the lessons that don't always make it into our conversations

1:14.5

with guests. Because at the end of the day, you are the CEO of your own health. And for many of you,

1:19.8

your family's health too. And you might not feel it all the time, but you have far more power

1:24.3

in agency than you realize. I'm glad you're here.

1:33.8

This episode is brought to you by Function Health, empowering you to live 100 healthy years with over 160 lab tests for just $365 a year and use the code mark 2026 to get $50 off

1:41.7

your membership.

1:43.1

Hormone replacement therapy is one of the most talked about and most misunderstood topics

1:46.9

in women's health right now.

1:48.2

For some, it's seen as a game changer.

1:50.5

For others, it still feels confusing or even risky.

...

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