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The Human Upgrade with Dave Asprey

Memory, Psychedelics, and Biohacking with Dr. Manoj Doss : 1187

The Human Upgrade with Dave Asprey

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.6 • 7.3K Ratings

🗓️ 6 August 2024

⏱️ 94 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

In this episode of The Human Upgrade, Dr. Manoj Doss, a neuroscientist at the University of Texas at Austin Dell Medical School, explores the fascinating intersection of psychedelics, memory, and cognitive enhancement. Drawing from his extensive research, Dr. Doss dives into how psychoactive substances like THC, ketamine, and psychedelics can alter memory formation, consolidation, and retrieval. He challenges the conventional understanding of memory by revealing how these substances might disrupt traditional memory processes while potentially opening new pathways for learning and cognition. 

You'll discover how different drugs impact your brain's ability to encode and recall information, the surprising effects of psychedelics on semantic and episodic memory, and the role of the hippocampus in shaping our personal narratives. Dr. Doss also delves into the potential benefits and risks of cognitive enhancers like nicotine and modafinil, offering insights into their effects on memory and brain function. 

Dr. Doss provides a nuanced perspective on the malleability of memory, the ethical implications of memory manipulation, and the complex relationship between trauma, memory, and psychedelics. This episode is essential for anyone interested in the cutting-edge science of memory, the therapeutic potential of psychedelics, and the quest to enhance cognitive performance. 


Timestamps: 

  • 00:00:01 — Opening 
  • 00:01:39 — Introduction to Dr. Manoj Doss 
  • 00:03:20 — The Impact of Psychedelics on Memory 
  • 00:05:50 — The Predictive Processing Framework and Mind Models 
  • 00:13:22 — Alcohol and Retrograde Facilitation: Enhancing Memory Post-Study 
  • 00:19:00 — Differences Between Episodic and Semantic Memory 
  • 00:22:57 — The Role of the Hippocampus in Memory Formation 
  • 00:32:35 — Exercise, BDNF, and Memory Enhancement 
  • 00:42:29 — The Complex Relationship Between Psychedelics and Neurogenesis 
  • 00:52:16 — The Fallibility of Memory and False Memory Formation 
  • 01:09:04 — The Influence of Nicotine, Modafinil, and Other Cognitive Enhancers 
  • 01:30:34 — Closing Remarks 


Sponsors: 

  • ARMRA | Go to TryARMRA.com and use the code DAVE to get 15% off your first order. 
  • Leela Quantum | Head to LeelaQ.com/Dave for 10% off. 


Resources: 

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcript

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0:00.0

You're listening to the human upgrade with Dave Asprey.

0:04.0

You're listening to the human upgrade with Dave Asprey.

0:11.0

Today we're going to talk memory, but not just any memory, we're

0:16.3

going to talk psychedelics and memory. Now if you're about to say I'm not going to

0:21.5

listen to this a bunch of people talking about

0:23.2

psychedelics. There's shamanic and journeying use for personal developments or

0:29.6

healing or spiritual things. There's also medical use for fixing things in your brain and

0:37.2

there's also a huge difference in dosing. Small doses of psychedelics have a very different effect and some of this has directly to do with longevity and with cognitive performance.

0:48.5

And if you've been listening for any of the last 10 years, you know that longevity and cognitive performance are two of the main pillars of biohacking.

0:56.4

And biohacking itself is now a $63 billion industry, which is amazing starting, I guess this was 13 years ago, with 100 people

1:06.8

at a bar in San Francisco at the first biohacking conference when I started it.

1:11.0

We're now at 3,200 people. But the entire time, how do you improve

1:15.4

yourself? How to improve cognitive performance? How do you heal stuff that needs healing

1:19.6

including trauma? And how do you live longer than you think you can, which includes having a brain

1:25.9

that's young and flexible. That's what we're going to talk about today and very

1:30.3

specifically about your memory, because he wants to live a good life if you can't remember it when you're done.

1:35.5

Our guest today is Dr. Menage Doss. He's a scientist at the University of Texas at Austin Dell Medical School.

1:44.4

And that's a mouthful.

1:45.8

I know.

1:46.8

Could they add some more?

1:48.2

Yeah, it's a weird thing about med schools sometimes want to have that extra title.

1:53.0

Nice.

...

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