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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Meloxicam Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 5 October 2023

⏱️ 12 minutes

🧾️ Download transcript

Summary

I discuss meloxicam pharmacology, adverse effects, drug interactions, and much more on this episode of the Real Life Pharmacology Podcast.



Meloxicam tends to have a greater affinity to COX-2 versus COX-1. I discuss what this means clinically on this episode.



Important meloxicam drug interactions include anticoagulants, antiplatelet medications, renal impairing drugs, and lithium amongst others.



Meloxicam has a longer half-life than many NSAIDs and because of this can be dosed once daily for pain relief.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Derek Christensen,

0:05.4

and I thank you so much for listening today. As always, go check out real-life pharmacology.com. Get your

0:11.3

free 31-page PDF on the top 200 drugs. It's a great study guide, no-brainer for those in clinical

0:18.6

practice or those going through pharmacology courses.

0:21.6

So simply an email, we'll get you access to that.

0:24.4

We also get you updates when we've got other new content available as well.

0:30.3

All right, let's get into the drug of the day today, and that is moxacam.

0:36.0

Brand name of this medication is Mobek.

0:38.9

And this is an insed.

0:40.8

Just a quick reminder, insed stands for non-steroidal, anti-inflammatory drug.

0:46.8

Some of the common ensets, ibuprofen, naproxin, those are over-the-counter,

0:52.0

and probably the two most common that I see in practice.

0:55.4

But I do occasionally see molyxicam.

0:58.8

So with that mechanism of being an N-Sed, this medication inhibits Cox enzymes,

1:07.5

and specifically Cox 1 and Cox 2.

1:11.6

That ultimately reduces prostaglandin synthesis,

1:15.6

which can lead to a reduction in pain and inflammation.

1:21.6

Now let's talk specifically about Meloxicam.

1:24.6

Meloxicam tends to prefer Cox 2 over Cox 1.

1:32.3

Now, as you increase doses, that selectivity tends to go away,

1:37.3

and you get Cox 1 and Cox 2 inhibition.

1:41.3

But what that means is if we've got a little bit of a preference towards cox two inhibition

...

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