Hey, all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Derek Christensen.

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All right. Let's get into the drug of the day today, and that is Spironal Actone.

Brand name of this medication is aldactone.

This is a potassium sparing diuretic.

Now mechanistically, how does this work?

The other classification is it's an aldosterone antagonist.

So it binds where aldosterone is going to bind on receptors

and ultimately blocks that aldosterone binding.

By doing that, we're going to increase sodium chloride elimination, as well as we're going to

increase water excretion.

So this is, again, a potassium sparing diuretic, so it causes some of that water excretion.

Now, as you can can imagine potassium is spared.

So potassium goes back into the bloodstream and that's why we can have elevated potassium levels with this medication. So that's how the drug works. Now what conditions,, disease states, do we use this medication in?

So first and foremost, it is classified as an antihypertensive, so you may see it for that.

Usually it's a little bit more refractory cases.

So, for instance, you know, you're usually going to see your calcium channel blocker,

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