Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5
Lifespan with Dr. David Sinclair
Lifespan Communications LLC
4.9 • 4.8K Ratings
🗓️ 2 February 2022
⏱️ 59 minutes
🧾️ Download transcript
Summary
In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.
Thank you to our sponsors:
- Athletic Greens - https://athleticgreens.com/sinclair
- InsideTracker - https://insidetracker.com/sinclair
- Levels - https://levels.link/sinclair
Our Patreon page: https://www.patreon.com/davidsinclair
Lifespan book: https://amzn.to/3sUqurT
Dr. David Sinclair Social:
To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com.
Matthew LaPlante's Social:
Timestamps:
(00:00:00) Kicking Off Episode Five: Interventions on the Cutting Edge
(00:02:39) Expressing Gratitude to the Sponsors
(00:05:28) Testosterone Replacement Therapy
(00:10:09) Human Growth Hormone
(00:13:56) Peptide Supplementation and Regenerative Signaling
(00:18:11) MOTS-c, Humanin, and Other Peptides
(00:25:05) Exosome Therapy
(00:31:56) A Primer on Stem Cells and Yamanaka Factors
(00:37:59) Stem Cell Aging and Cord Blood Banking
(00:41:42) The Therapeutic Potential of Stem Cells
(00:43:37) Cellular Reprogramming
(00:51:35) Resetting the Aging Clock
(00:56:50) The Future Looks Bright
(00:58:15) Next Week’s Episode: External Aging
(00:58:36) Subscription and Support Options
For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website.
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Title Card Photo Credit: Mike Blabac
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
Transcript
Click on a timestamp to play from that location
| 0:00.0 | Welcome to the Lifespan podcast where we discuss the science of aging and how to be healthier at any stage of life. |
| 0:10.0 | I'm Davies Sinclair. I'm a professor of genetics at Harvard Medical School and I'm co-director of the Polyff Glenn Center for Biology of Aging Research. |
| 0:19.0 | This podcast series is about why we age and why we may not have to, things you can do today, |
| 0:25.0 | and going forward to increase your wellness and to potentially live a much longer healthier life. |
| 0:31.0 | We've talked about the biology of aging, we've talked about things that you can do at home, preferably under the supervision of your doctor, |
| 0:38.0 | and today we're going to talk about things that you definitely will be talking to and requiring a doctor's supervision to do, |
| 0:45.0 | and even things that your doctor is unable to do, but potentially in the future may be able to. |
| 0:51.0 | I'm joined today by my co-host and my co-author, the lovely Matthew Lapland. Hey Matt. |
| 0:57.0 | We're back. We're doing it again. |
| 0:59.0 | We are definitely doing it. Today we're doing a deep dive into some somewhat controversial stuff. |
| 1:04.0 | This is a scary episode. |
| 1:06.0 | Well, I don't know if it's scary, but we have to do a disclaimer. |
| 1:09.0 | I think we have to say that what we're going to talk about today, a lot of it isn't approved by the FDA, but maybe in the future, |
| 1:15.0 | and some things that were available until recently, and were banned by the FDA, and are currently available only offshore. |
| 1:23.0 | Just as was the case when we had the conversation about drugs and supplements, and maybe even more so in this case, |
| 1:30.0 | there's a lot of misinformation out there about a lot of things that we're going to be talking about today, |
| 1:37.0 | these potential avenues for addressing longevity. |
| 1:41.0 | We're going to try to cut through that, but we are not doctors of the physician type. |
| 1:47.0 | That's right. I'm a PhD in genetics. I'm not a physician. |
| 1:50.0 | And so the things we've talked about in this series should always be done with the supervision and advice from your physician. |
| 1:56.0 | Yeah. Podcasts is no substitute for a physician. |
| 1:59.0 | That's right. But I'm a scientist. I can read the scientific literature. |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Lifespan Communications LLC, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Lifespan Communications LLC and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2025.