NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4

Lifespan with Dr. David Sinclair

Lifespan Communications LLC

Health & Fitness

4.9 • 4.9K Ratings

🗓️ 26 January 2022

⏱️ 71 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted. Correction and clarification: At time point 1:07:37, Dr. Sinclair says he takes 1 gram of Spermidine, but the active ingredient in the capsules is 1-2 milligrams. We apologize for the confusion. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Dr. David Sinclair Social: Instagram Twitter Facebook To stay up to date with David's work to democratize biological age testing and insights, visit tallyhealth.com. Matthew LaPlante's Social: Twitter Timestamps: (00:00:00) Kicking Off Episode Four: Longevity Molecules (00:02:15) Thanks the Sponsors (00:04:46) An An Additional Boost Beyond Adversity Mimetics (00:05:52) Drugs vs. Supplements and Highlight Points (00:09:54) Longevity Molecules Target the Survival Circuit (00:11:33) NAD Boosters (00:13:32) Nicotinamide Riboside (00:21:26) Nicotinamide Mononucleotide (00:29:22) NAD Intravenous Drips (00:32:45) Bioavailability of NAD Boosters (00:33:40) NAD and Cancer (00:35:33) Resveratrol (00:42:26) Red Wine and the French Paradox (0043:08) Fisetin and Quercetin (00:47:09) Rapamycin and Rapalogs (00:49:10) Spermidine (00:51:27) Metformin (01:00:27) Berberine (01:02:43) Dr. Sinclair’s Protocol for Longevity Molecules (01:08:51) Wrap-up and Next Week’s Episode: Interventions on the Cutting Edge (01:09:52) Options for Subscription and Support For the full show notes, including the peer-reviewed studies, visit the Lifespan podcast website. Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

Transcript

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0:00.0	Welcome to the Lifespan podcast where we discuss the science of aging and how to be healthier at any stage of life.
0:09.2	I'm David Sinclair. I'm a professor at Harvard Medical School and co-director of the Paul F. Glenn Center for Aging Research
0:15.8	And I'm joined today by my lovely co-author and co-host Matthew Lapland. Hey, hey, we do them.
0:22.8	Feel good to have it again. We are. We're here today to talk about
0:26.0	how to live longer and better as part of this podcast series. Yeah, the series.
0:31.4	The things that you can do to slow stop and reverse aging. That is true. And today is going to be a really interesting one.
0:38.9	This is going to be the one that everybody, I mean, this is the one that everybody's been begging for.
0:42.6	That is true. We've been monitoring the responses to tweets and Instagram posts and
0:49.0	most of them are David just tell us what to take. The nice ones. Yeah, some of those aren't very nice either,
0:55.3	but yeah, please, please, please. Should I take NR? Should I take NMN? What should I do with Metform?
1:00.6	And we're going to be talking about all of that today. We are. And our research team has been spending weeks on this.
1:06.6	And if you can't see I'm actually sitting in front of many pages of notes here, we're going to go deep dive into what is fact
1:13.5	and what is not fact, what is known, what is not known, because there's so much misinformation out there, especially with supplements.
1:18.8	Yeah. We do need to say we usually take a moment to think our sponsors. We're going to do that, of course, but we also have to take a moment to say we are not medical doctors.
1:29.3	We are not medical doctors. We are not medical doctors. What he said. I'm a PhD. I'm a researcher. I can read the literature. I've been doing it for the last 30 years.
1:39.4	I distill that for everybody. But of course, if you want to try supplement or even change your diet radically, please talk to your physician before you change any thing.
1:48.7	Because some of the things we'll talk about today can affect your body in hopefully many good ways, but sometimes can be dangerous depending on the person and everybody's different.
1:57.7	And what we want to do is give people the ability to have a more intelligent and formed conversation with their physician.
2:04.3	Exactly. Okay. With that out of the way, now we should thank our sponsors.
2:09.5	Let's do that. Because this podcast is free to anybody who wants to watch or listen. Our first sponsor is levels.
2:16.7	Levels is an app that syncs with a continuous glucose monitor, which they provide and it interprets your glucose data for you.
2:23.7	I've been so impressed by levels that I've recently joined them as an advisor. Monitoring your blood glucose allows you to see how different foods impact you.
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