May 22 2026 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 22 May 2026
⏱️ 32 minutes
🧾️ Download transcript
Summary
Three more digoxin trials, yet another GLP-1 drug on the horizon, vagal nerve stimulation, trial inside baseball, and more on lipid guidelines are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I More About Low-dose Digoxin in HF — The DECISION Trial(s)
- DECISION Trial https://www.nature.com/articles/s41591-026-04406-6
- Digitalis Glycosides in HF — JAMA Meta-Analysis https://jamanetwork.com/journals/jama/fullarticle/2848972
- DIGIT-HF Trial https://www.nejm.org/doi/10.1056/NEJMoa2415471
- RADIANCE Trial (1993) https://www.nejm.org/doi/full/10.1056/NEJM199307013290101
- DECISION Withdrawal Study https://doi.org/10.1093/eurheartj/ehag385
- Digoxin Discontinuation vs Continuation in Chronic HF https://doi.org/10.1016/j.amjcard.2007.02.099
II Yet another GLP-1 Drug Announced this Week
Lillly News Release on Retatrutide https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-delivered-powerful-weight-loss
III A Big Story in HF Science – Vagal Nerve Stimulation in HFrEF
- ANTHEM HFrEF trial https://doi.org/10.1016/j.jacc.2026.03.040
- Editorials
An Unfinished ANTHEM https://doi.org/10.1016/j.jacc.2026.04.033
When Trials Stop Prematurely https://doi.org/10.1016/j.jacc.2026.03.039
IV Lipid Guideline News
Lipid Guidelines: Four Major Concerns
https://www.medscape.com/viewarticle/lipid-guidelines-four-major-concerns-2026a1000fim
- Editorial: Time to Move Beyond the Statin Nocebo Effect https://www.jacc.org/doi/10.1016/j.jacc.2026.04.002
- Correspondence: SAMSON N-of-1 Trial of Statin, Placebo, or No Treatment https://www.nejm.org/doi/full/10.1056/NEJMc2031173
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Questions or feedback, please contact news@medscape.net
Transcript
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| 0:00.0 | You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology. |
| 0:05.4 | This podcast is intended for health care professionals only. |
| 0:08.8 | Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape. |
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| 0:37.7 | Medscape AI, trusted medical intelligence. |
| 0:41.2 | Hi, everyone. |
| 0:42.1 | This is John Mandrola from the Heart.org Medscape Cardiology, |
| 0:46.2 | and this is this week in cardiology for May 22, 2026. |
| 0:51.4 | This week, three more dejoxin trials, yet another GLP drug on the horizon, vagal nerve stimulation, trial inside baseball, and more on the lipid guidelines. |
| 1:04.0 | So I want to talk first about low-dose dejoxin and heart failure, the decision trial. And I almost missed this |
| 1:13.1 | big dejoxin trial. At the ESC Heart Failure Congress in Vienna last weekend, Professor Dirk, Jan |
| 1:20.4 | Van Valdheisen from Groningen, of Netherlands, and I'm sorry, if I mispronounced all that, presented results of a decision |
| 1:28.8 | trial of low-dose dejoxin in patients with Hefref. The results were published simultaneously in |
| 1:35.0 | nature medicine about 10 days ago, and I missed them last week, even though I discussed the highly |
| 1:41.0 | positive DIG-R-H-D trial of dejoxin in patients with rheumatic disease. |
| 1:46.6 | The thing is, the decision trial has been anticipated since the 2025 publication of the |
| 1:51.9 | positive but statistically fragile results of the Digit HF trial. |
| 1:57.4 | Decision randomized 1,000 patients with symptomatic heart failure in a reduced ejection fraction, |
... |
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