Low Muscle Mass: Common in Cancer, Heart Disease

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 29 March 2023

⏱️ 12 minutes

🔗️ Recording | iTunes | RSS

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Summary

Low muscle mass is higher than expected in people recently diagnosed with cancer and cardiovascular disease. Resistance exercise and nutrition may help prevent these chronic diseases.

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Link to research & images: https://bit.ly/3ZH5Ok1

References:

Morlino, D. et al. Prevalence of Sarcopenia in Women with Breast Cancer. Nutrients 14, 1839 (2022).

Jeznach-Steinhagen, A. et al. Higher Muscle Mass and Higher Serum Prealbumin Levels Are Associated with Better Survival in Hemodialysis Patients during a Five-Year Observation Period. Nutrients 15, 1237 (2023).

Key Takeaways:

00:36 Muscle enhances survivability from chronic disease.

01:10 There was a significant survival benefit from higher quantities of muscle. In chronic kidney disease.

02:00 Resistance training enhances longevity and prevents a variety of disease states.

02:10 Independent of fat mass, survival was higher in those with higher muscle mass.

02:45 Lower muscle mass reflected a worse survival rate in dialysis patients.

03:30 A sudden drop in albumin is an ominous marker, indicating lower survival rates.

07:20 Sarcopenia is found in 14% of breast cancer patients and 1 in 3 had pre-sarcopenia.

08:30 People with low muscle mass have a higher toxicity associated with chemotherapy drugs and have worse outcomes.

10:02 We need to prioritize protein, sleep, recovery, and intense physical activity that involves resistance training.

10:50 Loss of lean mass better predicts a cardiovascular event compared to fat gain.

Transcript

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0:00.0	As you likely know by now, muscle mass is very protective.
0:02.7	In today's show, we're going to talk about two recently published studies that found
0:05.2	that muscle mass helps enhance survival and reduces the odds of death in people who
0:09.8	have chronic kidney disease as well as breast cancer.
0:12.7	Now, I'm not the only one that's been talking about this.
0:14.8	We know Dr. Gabriel Alliance, Sean Baker.
0:16.9	Many other people have been highlighting the important protective effect of muscle tissue,
0:21.4	not just highlighting the deleterious effects of increased fat mass.
0:24.9	It seems that as a society, many people are focused on weight loss, on losing fat,
0:29.4	losing weight, but really should be shifting our framework in the paradigm to supporting
0:34.6	muscle mass because it turns out that in people with chronic disease such as breast cancer
0:39.4	or chronic kidney disease, the amount and independent effect of muscle that it has or
0:44.7	in parts on enhancing survivability in these complex chronic disease states is now
0:49.6	quantifiable.
0:50.6	And today, we're going to talk more about that, particularly in patients with chronic
0:53.9	kidney disease.
0:54.9	I know this title is a little bit jargonistic, but let's talk about this paper titled,
0:58.5	Higher Muscle Mass and Higher Serum Pre-Albumin Levels are associated with better survival
1:03.8	in hemodialysis patients during a five-year observational period.
1:07.4	Now, essentially what these researchers found is when looking at muscle mass using a bio-impedance
1:13.6	analysis, so this is something that you can readily do at most gyms and fitness centers
1:17.5	now, is look at a bio-impedance, which looks at phase angle.
	...

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