Longevity Scientist Shares Top Strategies for Improving Your Health Span w/ Matt Kaeberlein, PhD

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 6 September 2024

⏱️ 90 minutes

🔗️ Recording | iTunes | RSS

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Summary

Today’s show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases.

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Link to show notes: https://bit.ly/4gdmxES

Key Takeaways:

02:44 Pillars of health: eat, sleep, move, connect.
10:30 Eating protein and exercise can turn up mTOR.
15:20 High dietary protein and resistance training preserves muscle while aging.
19:20 Longevity research is underfunded.
25:10 Obesity was rare 50 years ago.
26:25 Fasting, and time restricting eating may not increase longevity.
30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.
34:40 Resveratrol is not a longevity drug.
36:45 Spermidine is an autophagy booster.
38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.
42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.
44:45 Metformin does not corelate to reduced all-cause mortality.
47:30 NAD is a co-factor required for thousands of metabolic reactions.
52:55 Some epigenetic signatures are predictive of future health outcomes.
54:17 Facial imaging using AI can predict future health outcomes.
58:17 Dunedin Pace measures the rate of aging.
59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.
01:04:00 Senescent cells are cells that do not do their job and refuse to die.
01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

Transcript

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0:00.0	All you have to do is look at pictures from the 1970s.
0:02.4	Just look at the shapes of people, right?
0:04.4	Fundamentally different.
0:05.4	You did not see obesity, or if you did, it was extremely, extremely rare
0:10.8	in the 1970s.
0:12.2	Now, I don't know what the statistics are. 50 plus
0:14.4	percent of Americans are obese, right? That is purely environmental.
0:18.3	Genetics have not changed in 50 years. So you probably don't know this but I have a
0:21.9	long history with Resveritrol.
0:23.0	Resveritrol of course is the miracle molecule, red wine, and I was one of the scientists who first
0:28.8	debunked that whole longevity piece. Again, not saying there's no benefits to Resveritrol, it is not a longevity one.
0:34.2	But even then, I rationalize drinking red wine.
0:38.0	My sort of current speculation around NED precursors is I think that boosting NAD for some people if you have
0:46.2	particularly you know a high level of mitochondrial dysfunction or metabolic
0:50.7	dysfunction for those people it may be beneficial. I think for the
0:56.0	average person is probably not going to move the needle. There also may be some
0:58.8	specific neurodegenerative diseases like Parkinson's disease where there's
1:02.2	some intriguing clinical trial data.
1:04.0	Today's show with MacCerebline is loaded with amazing information.
1:13.7	I strongly suggest that you look at the show notes and the time stands because
1:16.6	towards the end we talk a lot about Rapomyosin, Met Foreman, the current state of
1:20.4	testing and different tools to assess your biologic age and pace of
	...

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