Longevity Scientist Shares Top Strategies for Improving Your Health Span w/ Matt Kaeberlein, PhD

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Nutrition, Medicine, Health & Fitness

4.8 • 1.2K Ratings

🗓️ 6 September 2024

⏱️ 90 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Today’s show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases.

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Link to show notes: https://bit.ly/4gdmxES

Key Takeaways:

02:44 Pillars of health: eat, sleep, move, connect.
10:30 Eating protein and exercise can turn up mTOR.
15:20 High dietary protein and resistance training preserves muscle while aging.
19:20 Longevity research is underfunded.
25:10 Obesity was rare 50 years ago.
26:25 Fasting, and time restricting eating may not increase longevity.
30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.
34:40 Resveratrol is not a longevity drug.
36:45 Spermidine is an autophagy booster.
38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.
42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.
44:45 Metformin does not corelate to reduced all-cause mortality.
47:30 NAD is a co-factor required for thousands of metabolic reactions.
52:55 Some epigenetic signatures are predictive of future health outcomes.
54:17 Facial imaging using AI can predict future health outcomes.
58:17 Dunedin Pace measures the rate of aging.
59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.
01:04:00 Senescent cells are cells that do not do their job and refuse to die.
01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

Transcript

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0:00.0	All you have to do is look at pictures from the 1970s. Just look at the shapes of people, right? Fundamentally different. You did not see obesity or if you did, it was extremely, extremely rare in the 1970s. Now, I don't know what the statistics are. 50 plus percent of Americans are obese, right? That is purely environmental. Genetics have not changed in 50 years. So you probably don't know this,
0:21.6	but I have a long history with resveratrol. Resveratrol, of course, is the nirical molecule of red
0:25.7	wine. And I was one of the scientists who first debunked that whole longevity piece. Again,
0:30.8	not saying there's no benefits to resveratrol, it is not a longevity. But even then,
0:35.2	I rationalized drinking red wine wine my sort of current speculation around
0:40.8	n-d precursors is I think that boosting n-d for some people if you have particularly you know
0:47.9	a high level of mitochondrial dysfunction or metabolic dysfunction for those people it may be
0:53.3	beneficial I think for the average person is probably not going to move the needle they're also or metabolic dysfunction. For those people, it may be beneficial.
0:56.6	I think for the average person who's probably not going to move the needle.
0:58.0	There also may be some specific neurodegenerative diseases
1:00.4	like Parkinson's disease
1:01.5	where there's some intriguing clinical trial data.
1:10.1	Today's show with Matt Clearbellblind is loaded with amazing information.
1:13.7	I strongly suggest that you look at the show notes and the timestance,
1:16.3	because towards the end, we talk a lot about rapamycin, metformin,
1:19.6	the current state of testing and different tools to assess your biologic age and pace of aging.
1:24.3	He also talks about and debunks some of the common myths about dietary supplements
1:27.6	that have been purported to slow down your pace of biologic aging. We talk about other lifestyle
1:32.7	factors such as socialization, exercise, nutrition, and more. It's a phenomenal show brought to you
1:38.2	by myoscience nutrition. So as you know, exercise is one of the best interventions that you can
1:42.7	implement right now to not only help
1:45.1	improve your health right now, but slow down the pace of aging and optimize and prevent
	...

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