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Medgeeks with Andrew Reid

Liver Series: Liver Disease of Pregnancy

Medgeeks with Andrew Reid

Medgeeks

Education, Medicine, Health & Fitness

4.8 • 997 Ratings

šŸ—“ļø 11 September 2023

ā±ļø 11 minutes

šŸ§¾ļø Download transcript

Summary

In this episode of our Liver Series, we will discuss a couple of liver diseases that may occur during pregnancy: intrahepatic cholestasis of pregnancy (ICP) and acute fatty liver of pregnancy (AFLP).

Intrahepatic cholestasis is a liver condition that occurs late in pregnancy. It's caused by a backup of bile acids in the liver. Acute fatty liver is a rare, but serious liver disease that occurs in the third trimester and is caused by a buildup of fat in the liver.

Join Dr. Niket Sonpal as he goes over signs and symptoms of ICP and AFLP as well as the different treatments to help your patient out. He will also talk about the importance of early diagnosis and treatment for these conditions.

September 11, 2023

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Transcript

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0:00.0

Besides being your favorite podcast host, I'm also a full-time

0:03.8

Gashrentrologist and one of the things that I come across whenever I'm doing

0:07.8

consultations in the hospital are elevated liver biochemical tests in

0:12.2

pregnant patients.

0:13.7

And this can freak out the hospital team and it can also scare the OBGYN team, but more importantly,

0:19.5

it's also very worrisome for the patient themselves. Whenever my team gets paged about a new consult on the OOGY and floor,

0:26.0

we have to think to ourselves where there are two main categories of liver disease during pregnancy.

0:30.0

There are those diseases that are going to be primary liver diseases known as

0:34.5

intra-epatic colostasis of pregnancy and acute fatty liver of pregnancy and then

0:39.5

there are actually going to be systemic diseases that occur during pregnancy that have

0:43.5

hepatic manifestations like severe pre-aclamia, help syndrome, and hyperemesis gravodarum.

0:49.4

What we're going to be discussing today in this week's podcast are going to be the

0:52.4

primary liver diseases of pregnancy, that being

0:55.0

intrepatic colostasis and acute fatty liver. I'm Dr. Nakeets-on-Paul

0:59.0

your friendly-neabered internist and gastromatologist and welcome to the

1:02.0

show. Now before we jump into these two diseases, let's go over some signs and symptoms on the physical exam and labs of things that happen during pregnancy that sometimes we see in chronic liver disease but are actually normal findings.

1:27.0

The first major one are going to be spider angiomas and Palmer-era FEMA.

1:32.0

These are classically associated with chronic liver disease and cirrhosis,

1:35.0

but are actually very common during pregnancy,

1:37.0

and believe it or not, after delivery, they usually go away.

1:41.0

The reason these things occur is from the high estrogen level from pregnancy and in cirrhosis it occurs because the estrogen isn't being broken down by the liver.

1:48.8

The next thing we're going to also notice is that the liver might be displaced upward and appear somewhat big or it actually

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