Linezolid Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 28 March 2019

⏱️ 13 minutes

🔗️ Recording | iTunes | RSS

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Summary

Linezolid is an antibiotic used for bacterial infection. It primarily works by inhibiting bacterial protein synthesis.

Linezolid is primarily bacteriostatic against most bacteria which means that it inhibits the growth and doesn't necessarily kill the bacteria itself.

Caution must be used with linezolid and serotonergic drugs as there is a risk for serotonin syndrome. Clinical risk/benefit analysis needs to be done.

Linezolid overall has good coverage for VRE and MRSA. It is an option for MRSA pneumonia where daptomycin is not.

Linezolid has both an oral and an IV option which allows for good continuity of inpatient and outpatient use.

Transcript

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0:00.0	Hey, all, thanks for listening today. Eric Christensen here, host of the Real Life Pharmacology podcast.
0:07.0	I am a pharmacist, and people have certainly asked how to contact me, reach out to me,
0:13.8	with questions or sponsorships or other things like that. LinkedIn is a great way to track me down.
0:20.1	So Eric Christensen, FarmD, you can
0:22.7	track me down there, as well as through the website, real life pharmacology.com. So that's probably
0:28.2	the easiest way to get in touch with me. Thank you to all those who have left a rating and review.
0:33.2	If you like the podcast, I would strongly encourage you to do so. That helps us in iTunes and rankings
0:39.3	and all that good stuff. It allows us to be found by more people. So with that, let's get
0:46.1	into it. I'm talking about la nasalid today. The brand name of this medication is Zyvox,
0:58.4	and this medication is an antibiotic for infection.
1:05.1	We've got oral and IV capabilities there that we can give this medication.
1:13.4	Primarily, you know, it can be used for a variety of different infections, some off-label, and things like that. Primarily, you know, it can be used for a variety of different infections, some off-label and things like that.
1:20.0	Primarily, probably skin and soft tissue infections and pneumonia are going to be the most common,
1:24.3	but you may see it for various other things as well.
1:33.1	So there's two, at least really big bugs in my experience, that lenaesalid can help treat. Linasalid is kind of one of those down-the-line type of drugs due to cost and due to its
1:41.0	coverage capabilities. So it's not going to be typically not going to be used for
1:49.5	empiric therapy where, you know, somebody's coming in with pneumonia, boom, you're going to give lanazolid.
1:55.8	No, that's not typically how that drug is going to be given. So the two specific bugs that it's really, really helpful in managing and treating are VRE,
2:08.9	which is vancomycin-resistant enterococcus.
2:12.1	So it's kind of right in the name, right, where if an anoreococcus bacteria is resistant to vancomycin,
2:21.9	vancomycin is considered one of our go-to drugs for a certain gram-positive bacteria,
2:29.5	and enterococcus is obviously one of those. VRE is a very resistant
	...

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