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Finding Genius Podcast

Lighting the Way – Nicolas C. Pégard, PhD, University of California, Berkeley – How Neuroscientists Are Using Light to Understand the Brain and Neural Circuit Dysfunction

Finding Genius Podcast

Richard Jacobs

Medicine, Health & Fitness

4.41K Ratings

🗓️ 20 June 2018

⏱️ 25 minutes

🧾️ Download transcript

Summary

Nicolas C. Pégard, Ph.D., a University of California, Berkeley neuroscientist will provide an illuminating overview of his work to develop optical systems that are designed to help neuroscientists solve problems. Of particular interest to Berkley, neuroscientist is a method known as optogenetics. Optogenetics is a process that uses light to modify molecular events in a specific manner, in living cells and organisms, which enables researchers to connect computers to the brain and focus on specific neurons. Essentially, the cell’s genetic toolbox is used to create proteins that are not naturally present within the brain, a true combination process combining optics and genetics.
The Berkeley researcher will detail how his team uses holograms to create artificial patterns of neural activity that can mimic what the brain is doing when it is experiencing a thought or engaging in an action. This allows researchers to put the brain into a state that replicates what would happen if the brain had actually experienced a sensory stimulus. Pégard gives us a glimpse into the future of these techniques of neuroscience, some of which sound like they could be pulled straight from a big budget science fiction Hollywood movie plot. Case in point, this neural activity method could actually trick the brain into believing something has occurred that did not, or even place new ideas into the brain.
The discussion will detail how observation of the brain in a diseased state could lead to monumental advances in drug therapy for brain diseases, which may enable the development of higher efficacy drugs with minimal or no side effects. Further research could facilitate groundbreaking achievements in prosthetics, for if there can be communication with the brain that involves multiple thousands of neurons, prostheses could become higher functioning. Nicolas C. Pégard and neuroscience researchers foresee changes that could literally alter the course for human health and brain function, but for now, his team is taking it to step by step.

Transcript

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0:00.0

Welcome to Almost Here, Around the Corner of Future Technology Podcasts with Richard Jacobs.

0:07.0

Future Technologies Hoyts to transform our lives for better or worse or the focus of this podcast.

0:13.0

Almost here means these technologies are now here and starting to be used.

0:17.0

Or just around the corner, for Bitcoin to artificial intelligence,

0:21.0

3D printing, blockchain, virtual reality, and more.

0:25.0

Hello this is Richard Jacobs with Future Tech Podcast. My guest is Nicholas Pagard. He's a postdoc at Berkeley working in the

0:34.8

neuroscience lab. Nick how are you?

0:36.8

Very well how are you? Good good. Yeah I love talking to Beable at Berkeley

0:41.6

and you know the higher institutions because you guys are

0:44.6

working on amazing interesting stuff so tell me what's going on in the lab that you're

0:49.0

working on in particular. Oh so, I'm sorry, I'm heard.

0:55.0

Okay, I hope you can.

0:57.0

Yeah, I'll restart the question.

0:59.0

So, yeah, tell me what's, what's happening in the neuroscience lab that, you know, I know there's a lot going on in general, but what's happening in the neuroscience lab that you know I know there's a lot going on in general but what's your particular research about?

1:07.0

Oh all right so I did lost optical systems that are meant to help neuroscientists solve the problems that they're trying to solve and the questions they're trying to find answers to.

1:18.0

So I'm more of a technology developer person and what we do is we look at their problems and we say you know like for

1:25.5

that particular application you might need to have you know different kinds of apparatus

1:30.7

that is not available commercially so we develop the type of apparatus that is not available commercially so we develop

1:33.4

the type of apparatus that exactly needs to solve those problems and

1:36.5

one of the techniques that they are really after is called optogenetics it's this

1:41.6

way to make the brain cells, the neuron sensitive to light.

1:47.0

And this is something that can be done, but once you have done that, you need technologies that can allow you to connect the computer to the brain and say,

...

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