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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Levetiracetam Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 26 November 2020

⏱️ 13 minutes

🧾️ Download transcript

Summary

On this episode of the RLP podcast, I discuss levetiracetam pharmacology.



Levetiracetam is indicated for numerous types of seizures and possibly works by enhancing GABA activity.



Sedation and dizziness are two common adverse effects of levetiracetam.



On this episode, I discuss when and if we might do levetiracetam levels.



Levetiracetam tends to have much fewer drug interactions compared to older agents like phenytoin and carbamazepine.

Transcript

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0:00.0

Hey, all, welcome back to the Real Life Pharmacology podcast.

0:03.8

I'm your host, pharmacist Eric Christensen, and I thank you so much for listening.

0:08.3

If you'd like to track me down for comments, questions, anything there,

0:12.2

Eric Christensen, FarmD, B-CPS, B-C-GP on LinkedIn, that's probably the social media platform I'm most active on.

0:21.3

Or you can catch me at Med Education 101 at gmail.com.

0:28.3

And of course, I've got to remind you at real-life pharmacology.com.

0:33.0

We've got a free 31-page PDF on the top 200 drugs.

0:38.3

So it's a great little study guide where I lay out things that actually happen in clinical practice,

0:43.3

as well as things that frequently come up on pharmacology and or board exams.

0:51.3

So let's get into the medication I want to discuss today, and that is levateracetam.

0:58.0

Brand name of this medication is Kepra, and it can be used for seizure prophylaxis

1:04.5

and management of many different types of seizures in general.

1:10.6

Mechanistically, it's not actually really well understood how this medication works.

1:19.7

It's suspected it may have inhibitory action on voltage-gated calcium channels in the central nervous system.

1:30.0

And this may aid in promoting the action of GABA, which if you remember what GABA does,

1:37.9

it is an inhibitory type neurotransmitters.

1:42.0

So that's potentially, again, not totally well understood,

1:46.6

but potentially how it could help in managing seizure disorder.

1:53.4

Adverse effect profile, most common thing that I have seen in clinical practice by far is fatigue, potentially dizziness,

2:06.2

and then probably less common, you may see some psychiatric changes.

2:11.5

So whether that be agitation or anxiety, things like that.

2:16.6

Rare adverse effects,

...

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