Hey all, welcome back to the real life pharmacology podcast. I am your host, Eric Christensen,

and I thank you so much for listening. Hope you enjoy the episode today, but first want to remind you

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All right, so let's get into the medication of the day today, and that is fluconazole.

Brand name of this medication is diphlucan, and this is well known to be an antifungal medication.

Also, sometimes you'll hear it called an azol antifungal agent.

And this medication inhibits the action of lanosterol 14 alpha demethylase. And basically what that does is it helps produce ergosterol.

Now, ergosterol is necessary for fungal cell membrane formation.

So basically, by using fluconazole, we're blocking the production of necessary components

to basically build the cells, cell membrane. Now, what type of infections can fluconazole be used for?

Candidiasis, so that's, you know, things like thrush as well as vaginal candidiasis,

cryptococcus, off-label uses, you might see blastomycosis, tini infections.

So basically, there's a lot of different fungal infections that fluconazole

can be used for. Adverse effect profile. I would say in my experience, I've seen the medication

in general be pretty well tolerated as far as kind of mild demodurate dose limiting adverse effects

GI upset maybe some dizziness maybe a little bit of a headache has been reported in the literature

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