Timestamp Notes 00:02 – Dopey Wednesday theme song 01:03 – Dave reacts to Reddit saying he sounds like a radio announcer 02:00 – Film festival update: SVA Theatre / old Walter Reade Triplex 02:38 – Dave remembers growing up in Penn South 03:30 – Penn South flea market memories 04:35 – Dave says this is “not very dopey” and introduces Blake Mycoskie 05:45 – Traumatic Aunt Elsa flea market story 07:22 – Ian from Paris voicemail begins 08:10 – Vodka, kratom, and friend-with-benefits setup 09:31 – Kratom vomit explosion in the bathroom 11:43 – Ian praises Dopey socks 12:30 – Dave reacts to the “sexy vomit time” kratom story 14:03 – Dave asks for international voicemails 14:30 – Dave apologizes for falsely saying Chet Holmgren is gay 15:45 – Spotify comments begin 16:28 – Leah corrects Dave on Salvia and Sassafras 17:40 – Euphoria and Zach Noe Towers comments 18:00 – Amanda de Cadenet backlash 18:51 – Katz’s food and chicken soup/brisket secret 20:00 – White Claw relapse comments 21:17 – Justin Bagby recovery comment 22:20 – More Chet Holmgren corrections 23:21 – Patreon comments begin 24:00 – Rachel shares 27 days off alcohol and 7 days off coke 24:45 – Sassafras debate continues 26:20 – Lena Dunham, Girls, Knicks, and Zach Noe Towers praise 28:00 – Dave introduces Blake Mycoskie 29:10 – Blake joins; No Magic Pill and Shark Tank 30:10 – Shark Tank during COVID at the Venetian 31:30 – Dave talks about being addicted to Shark Tank 32:25 – Blake discusses psychedelics and funding Johns Hopkins research 34:20 – Blake on dopamine addiction, startups, racing, climbing, surfing 36:00 – Blake’s depression after selling TOMS 37:30 – Origin of TOMS: Argentina, polo, and shoes 40:00 – One-for-one shoe idea is born 41:00 – Dave talks about discomfort with “helping people” 42:00 – Blake explains AI therapy app Sonia 45:30 – Why TOMS took off with hipsters, Brooklyn, Vogue, and celebrities 48:00 – Blake discusses selling TOMS and moving to Jackson Hole 50:00 – Depression, shame, and chasing fixes 51:45 – Blake lists treatments he tried for depression 52:50 – Psychedelic experiences: Ayahuasca, MDMA, psilocybin, San Pedro, Ibogaine 53:40 – Ibogaine made Blake nauseous but gave no psychedelic effect 56:45 – Blake talks about getting off Abilify, Lamictal, Wellbutrin, and Klonopin 58:30 – Misdiagnosed as bipolar at a dinner party 59:40 – Blake describes suicidal depression and feeling imprisoned by his life 01:01:15 – Blake realizes he can blow up his life instead of ending it 01:03:40 – Thank God for Depression book 01:05:15 – Alternative to Meds Center in Sedona 01:06:00 – Brain zaps and pharmaceutical withdrawal 01:08:20 – San Pedro journey and discovering “I am enough” 01:10:35 – 40-day mantra meditation practice 01:12:50 – Photography project helps Blake regain connection and creativity 01:15:30 – Portrait of sober friend at the Dream Center 01:17:30 – Dave and Blake discuss photography and portraits 01:19:00 – Morning Water 01:20:00 – Enough bracelets and giving one to someone else 01:22:00 – No Magic Pill guests: Matthew McConaughey, Michael Pollan, Jewel 01:24:00 – Blake pushes back on Dave saying he doesn’t do Dopey to help people 01:26:30 – Dave jokes about MDMA and heroin with Oprah 01:27:00 – Advice for people getting off pharmaceuticals 01:28:30 – Blake stops drinking with Jasmine 01:29:30 – Psychedelics, no weed, no alcohol, quitting nicotine 01:31:00 – “Have you ever met somebody who actually was not enough?” 01:32:00 – Dave agrees to the 40-day “I am enough” challenge 01:32:35 – Dave wraps up Blake interview 01:33:00 – Dave jokes about “Great” t-shirts and Dopey vs. Phish