Klaviyo CMO Jamie Domenici on moving from AI as a tool to AI as an autonomous agent

The Agile Brand with Greg Kihlström®: Expert Mode Marketing Technology, AI, & CX

The Agile Brand

Business, Marketing

4.9 • 113 Ratings

🗓️ 20 May 2026

⏱️ 24 minutes

🔗️ Recording | iTunes | RSS

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Summary

If AI can now execute an entire marketing campaign from a single prompt, what is the new primary function of a marketing leader? While agility often requires adapting to new tools, it can also require fundamentally rethinking the operating model of a marketing organization. It’s about reallocating your most valuable resource—your team’s strategic thinking—to where it can have the greatest impact. Today, we're going to talk about the shift from AI as a tool to AI as an autonomous agent. We'll explore how these "agentic" AI systems, which can independently execute complex tasks based on strategic goals, are poised to redefine the marketing function, separating real value from hype and forcing us to reconsider the balance between human creativity and machine execution. To help me discuss this topic, I'd like to welcome back to the show, Jamie Domenici, CMO at Klaviyo. About Jamie Domenici Jamie is Chief Marketing Officer at Klaviyo, the only CRM built for consumer brands. She has served as the Chief Marketing Officer since August 2023. With more than 20 years of experience in SaaS Marketing, Jamie has become a pioneer in SMB Marketing and a champion for small businesses. Prior to Klaviyo, Jamie served as the CMO of GoTo, a provider of SaaS and cloud- based remote work tools for collaboration and IT management, and before that, she held various marketing leadership positions at Salesforce for over ten years. Jamie holds a B.A. in International Relations from California State University, Chico. Jamie lives in the San Francisco Bay Area with her husband and two daughters. Jamie Domenici on LinkedIn: https://www.linkedin.com/in/jdomenici/ Resources Klaviyo: https://www.klaviyo.com The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://aglbrnd.co/r/2868abd8085a9703 Drive your customers to new horizons at the premier retail event of the year for Retail and Brand marketers. Learn more at CRMC 2026, June 1-3. https://aglbrnd.co/r/d15ec37a537c0d74 We’re proud to be a media partner for #MAICON26 - Oct. 13-15! Learn how AI can power your marketing and business and help you grow smarter. Use code AGILE150 to save! https://aglbrnd.co/r/7fe458ced0f04658Reach your customers with Reddit. Spend $500 in ad spend, get $500 back in ad credit! Learn more: https://advertalize.com/r/491818c79fb1873fDon't miss We Make Future - the International Festival of Innovation in AI, Tech, and Digital Marketing, June 24-26 in Bologna. Learn more: https://aglbrnd.co/r/c80991afff416bb2The most influential minds in software, AI, and engineering leadership will be at WeAreDevelopers World Congress North America, September 23-25 in San Jose. Learn more: https://aglbrnd.co/r/60a7299222a7bcf1 Enjoyed the show? Tell us more at and give us a rating so others can find the show at: https://aglbrnd.co/r/faaed112fc9887f3 Connect with Greg on LinkedIn: https://www.linkedin.com/in/gregkihlstromDon't miss a thing: get the latest episodes, sign up for our newsletter and more: https://aglbrnd.co/r/35ded3ccfb6716ba Check out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company

Transcript

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0:00.0	Today we're going to talk about the shift from AI as a tool to AI as an autonomous agent.
0:05.0	We're going to explore how these agentic AI systems, which can independently execute complex tasks based on strategic goals,
0:12.0	are poised to redefine the marketing function, separating real value from hype and forcing us to reconsider the balance between human creativity and machine execution.
0:24.6	Welcome to Season 8 of the Agile Brand Podcast.
0:27.6	This season we're going all in on expert mode MARTEC, AI, and customer experience,
0:32.6	talking with the people and platforms behind the brands you know and love.
0:35.6	Again, I'm your host Greg Kilstrom, and I help Fortune 1000 companies make sense
0:40.3	of MARTEC, AI, and marketing ops.
0:42.6	Hit subscribe or follow to make sure you always get the latest episodes and leave us a rating
0:46.6	so others can find us as well.
0:49.2	And make sure you check out our sponsor Tech Systems, an industry leader in full-stack
0:53.4	technology services, talent services, and full-stack technology services,
0:54.5	talent services, and real-world adoption. For more information, go to TechSystems.com. Now let's dive in.
1:04.2	Tell me discuss this topic. I'd like to welcome back to the show, Jamie Domenici, CMO at Clavio.
1:10.0	Jamie, welcome back to the show. Hi, thanks for having me. Yeah, always great to talk with you and looking forward to talking about this with you. Before we dive in, for those that didn't catch the last episode you were on, why don't you give a little background on yourself and your role at Clavio? Well, I mean, first of all, come on, guys. You ought to tune in, but.. Thank you. Thank you. My name's Jamie Diminici. I'm the CMO at Clavio, so I run
1:32.3	marketing. And if you're not familiar with Clavio, we are a B2C marketing automation.
1:38.0	But we're not just marketing or marketing or service or data. And we're really powering this
1:43.1	new autonomous workflow for B2C
1:46.4	company. So automating your end-to-end experience for all of your customers in every
1:51.5	interaction that you have with them. Yeah, great, great. So yeah, let's dive in here and start,
1:57.2	I want to start by talking about the, really the shift to marketing strategy.
2:02.5	And certainly as a, as a CMO, you're probably feeling this from that perspective as well as from,
	...

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