Kicking Alzheimer's Butt & Your Questions with Dr. Richard Isaacson

Laugh Lines with Kim & Penn Holderness

Kim Holderness

Holderness Podcast, Self-improvement, Parenting, 40s, Laugh Line, Gen X, Penn Holderness, Laugh Lines, The Laugh Line, 50s, Kim Holderness, Aging, Getting Older, Humor, The Holderness Family, Marriage, Education

4.9 • 3.4K Ratings

🗓️ 5 May 2026

⏱️ 57 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

If you’ve been following along, you know Penn recently found out he has two copies of the APOE4 gene - basically the “high risk” genetic lottery for Alzheimer’s. And while we thought we were prepared for that news… we weren’t. It hit hard. For both of us. But this episode is not about fear. It’s about hope.

This week we are sitting down (again!) with Dr. Richard Isaacson (the brain behind Penn’s prevention plan and one of the leading voices in Alzheimer’s prevention) to answer YOUR questions. And wow, did you have questions. We discuss what to actually ask your doctor, what Penn is doing right now, prevention strategies that are showing promise, and how close we are to affordable, at-home Alzheimer’s risk testing. Spoiler: closer than you’d expect. But the biggest thing we discuss? Why genes are not your destiny.

We also get very real about the emotional side of this, like what it’s like to love someone who might face this disease, what caregiving actually looks like, and why doing something now matters so much. If you or someone you love has concerns about Alzheimer's, this show is for you. Because for the first time, this doesn’t feel like a ticking time bomb. It feels like something we can actually fight. We love to hear from you! Leave us a message at 323-364-3929 or write the show at podcast@theholdernessfamily.com. You can also watch our podcast on YouTube.

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Laugh Lines with Kim & Penn Holderness is an evolution of The Holderness Family Podcast, which began in 2018. Kim and Penn Holderness are award-winning online content creators known for their original music, song parodies, comedy sketches, and weekly podcasts. Their videos have resulted in over three billion views and over nine million followers since 2013. Penn and Kim are also authors of the New York Times Bestselling Books, ADHD Is Awesome: A Guide To (Mostly) Thriving With ADHD and All You Can Be With ADHD. They were also winners on The Amazing Race (Season 33) on CBS.

Laugh Lines is hosted and executive produced by Kim Holderness and Penn Holderness, with original music by Penn Holderness. Laugh Lines is also written and produced by Ann Marie Taepke, and edited and produced by Sam Allen. It is hosted by Acast. Thanks for listening!

Hosted on Acast. See acast.com/privacy for more information.

Transcript

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0:00.0	I think you and I were both holding on to hope that like you were going to be the one in your family that somehow miraculously, you know, defied the genetics.
0:09.0	And he and you convinced me that we're going to kick Alzheimer's ass.
0:13.9	Genes are not your destiny. You can win the tug of war against your genes.
0:17.1	I am convinced that you are 100% on the level in wanting everyone else to have this feeling
0:23.1	and making it as affordable and accessible as possible. So I can't thank you enough for that.
0:27.6	See the impact you've had on the field of Alzheimer's prevention. Y'all don't even know this.
0:31.2	Yeah, we get older every day. Got more wrinkles. That's okay. Yeah, we're laughing when we age.
0:37.8	Life is like a comedy stage.
0:41.4	And that's what we got laugh lines.
0:47.6	Hi, friends.
0:48.7	I'm Kim Holderness.
0:49.7	And I'm Penn Holderness, and this is Laughlines, and we are thrilled that you're here.
0:53.3	We are so excited you're here. This is going to be a great episode today. All are welcome, but especially those who traded garbage pale kids at the lunch table growing up. Garbage pale kids. Oh, remember those? Was that like, if you had garbage pale kids, were you like one of the cool people? Because I did not have those. You was just saying I didn't. You didn't have the garbage pale trading cards? No, I did not. The gasp, I just gus. Yeah. Oh, wow. Is that the past tense for gasp? I just learned something about my husband, and this changes sort of how I see you. Maybe I shouldn't be part of this show.
1:29.9	Okay.
1:30.5	Sorry.
1:31.1	We have to get right to do this.
1:32.5	Last month, we had a show with some life updates.
1:35.5	We talked about my ADHD.
1:37.4	But Penn talked about his update with Alzheimer's Prevention.
1:41.7	He talked about getting on a GLP 1 because there's some very early
1:45.4	research that suggest it may help prevent or delay Alzheimer's. And we put a clip from that
1:50.6	episode on our social media feeds and it got a lot of attention. I think we should just play
	...

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